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Nano Research

Article Title

Platinum-coordinated graphitic carbon nitride nanosheet used for targeted inhibition of amyloid β-peptide aggregation

Authors

Meng Li, Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China University of Chinese Academy of Sciences, Beijing 100039, China
Yijia Guan, Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China University of Chinese Academy of Sciences, Beijing 100039, China
Zhaowei Chen, Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China University of Chinese Academy of Sciences, Beijing 100039, China
Nan Gao, Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
Jinsong Ren, Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
Kai Dong, Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China University of Chinese Academy of Sciences, Beijing 100039, China
Xiaogang Qu, Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China

Keywords

amyloid disease, platinum, graphitic carbon nitridenanosheet, photooxygenation, amyloid β-peptide (Aβ)inhibitors

Abstract

Amyloid β-peptide (Aβ) aggregation is a critical step in the pathogenesis ofAlzheimer’s disease (AD). Inhibition of Aβ production, dissolution of existingaggregates and clearance of Aβ represent valid therapeutic strategies againstAD. Herein, a novel platinum(II)-coordinated graphitic carbon nitride (g-C3N4)nanosheet (g-C3N4@Pt) has been designed to covalently bind to Aβ and modulatethe peptide’s aggregation and toxicity. Furthermore, g-C3N4@Pt nanosheetspossess high photocatalytic activity and can oxygenate Aβ upon visible lightirradiation, remarkably attenuating both the aggregation potency and neurotoxicityof Aβ. Due to its ability to cross the blood-brain barrier (BBB) and its goodbiocompatibility, g-C3N4@Pt nanosheet is a promising inhibitor of Aβ aggregation.This study may serve as a model for the engineering of novel multifunctionalnanomaterials used for the treatment of AD.

Graphical Abstract

Publisher

Tsinghua University Press

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