Platinum-coordinated graphitic carbon nitride nanosheet used for targeted inhibition of amyloid β-peptide aggregation
amyloid disease, platinum, graphitic carbon nitridenanosheet, photooxygenation, amyloid β-peptide (Aβ)inhibitors
Amyloid β-peptide (Aβ) aggregation is a critical step in the pathogenesis ofAlzheimer’s disease (AD). Inhibition of Aβ production, dissolution of existingaggregates and clearance of Aβ represent valid therapeutic strategies againstAD. Herein, a novel platinum(II)-coordinated graphitic carbon nitride (g-C3N4)nanosheet (g-C3N4@Pt) has been designed to covalently bind to Aβ and modulatethe peptide’s aggregation and toxicity. Furthermore, g-C3N4@Pt nanosheetspossess high photocatalytic activity and can oxygenate Aβ upon visible lightirradiation, remarkably attenuating both the aggregation potency and neurotoxicityof Aβ. Due to its ability to cross the blood-brain barrier (BBB) and its goodbiocompatibility, g-C3N4@Pt nanosheet is a promising inhibitor of Aβ aggregation.This study may serve as a model for the engineering of novel multifunctionalnanomaterials used for the treatment of AD.
Tsinghua University Press
Meng Li,Yijia Guan,Zhaowei Chen,Nan Gao,Jinsong Ren,Kai Dong,Xiaogang Qu, Platinum-coordinated graphitic carbon nitride nanosheet used for targeted inhibition of amyloid β-peptide aggregation. NanoRes.2016, 9(8): 2411–2423