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Nano Research

Article Title

Hydrophilic bismuth sulfur nanoflower superstructures with an improved photothermal efficiency for ablation of cancer cells

Authors

Zhiyin Xiao, State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001, China
Chaoting Xu, State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China
Xiaohong Jiang, School of Medicine Science, Jiaxing University, Jiaxing 314001, China
Wenlong Zhang, State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China
Yuxuan Peng, State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China
Rujia Zou, State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China
Xiaojuan Huang, State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China
Qian Liu, College of Science, Donghua University, Shanghai 201620, China
Zongyi Qin, State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China
Junqing Hu, State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China

Keywords

bismuth sulfur, nanoflowers, photothermal agent, photothermal conversionefficiency, cancer therapy

Abstract

Nanomaterials with intense near-infrared (NIR) absorption exhibit effectivephoton-to-thermal energy transfer capabilities and can generate heat to ablatecancer cells, thus playing a pivotal role in photothermal cancer therapeutics.Herein, hydrophilic flower-like bismuth sulfur (Bi2S3) superstructures with uniformsize and improved NIR absorption were controllably synthesized via a facilesolvothermal procedure assisted by polyvinylpyrrolidone (PVP), which couldadjust the product morphology. Induced by an 808-nm laser, the as-preparedBi2S3 nanoflowers exhibited much higher photothermal conversion efficiency(64.3%) than that of Bi2S3 nanobelts (36.5%) prepared in the absence of PVP. Thiscan be attributed not only to the Bi2S3 nanoflower superstructures assembled by3-dimensional crumpled-paper-like nanosheets serving as many laser-cavitymirrors with improved reflectivity and absorption of NIR light but also to theamorphous structures with a lower band gap. Thus, to achieve the sametemperature increase, the concentration or laser power density could be greatlyreduced when using Bi2S3 nanoflowers compared to when using Bi2S3 nanobelts,which makes them more favorable for use in therapy due to decreased toxicity.Furthermore, these Bi2S3 nanoflowers effectively achieved photothermal ablationof cancer cells in vitro and in vivo. These results not only supported the Bi2S3nanoflowers as a promising photothermal agent for cancer therapy but alsopaved an approach to exploit new agents with improved photothermal efficiency.

Graphical Abstract

Publisher

Tsinghua University Press

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