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Nano Research

Article Title

Superfluorinated copper sulfide nanoprobes for simultaneous 19F magnetic resonance imaging and photothermal ablation

Keywords

19F magnetic resonanceimaging, photothermal therapy

Abstract

Copper sulfide (Cu7S4) nanoparticles coated with an ultra-high payload (~5.0 × 107fluorine atoms per particle) of fluorinated ligands (oleylamine functionalized3,5-bis(trifluoromethyl)benzaldehyde, 19FOAm) exhibited a single intense 19Fmagnetic resonance (MR) signal and efficient near infrared photothermalperformance in water medium. In vivo assessment revealed strong 19F MR signalsat cancerous lesions and effective inhibition of tumor growth after photothermaltreatment, indicating the great potential of these fabricated nanoprobes forsimultaneous 19F MR imaging and photothermal therapy.

Graphical Abstract

Publisher

Tsinghua University Press

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