Photothermal therapy by using titanium oxide nanoparticles
photothermal therapy, titanium oxides, biocompatibility, photothermal conversion
ABSTRACT The photothermal therapy (PTT) technique is regarded as a promising method for cancer treatment. However, one of the obstacles preventing its clinical application is the non-degradability and biotoxicity of the existing heavy-metal and carbon-based therapeutic agents. Therefore, a PTT material with a high photothermal efficiency, low toxicity, and good biocompatibility is urgently wanted. Herein, we report a titanium oxide-based therapeutic agent with a high efficacy and low toxicity for the PTT process. We demonstrated that Magnéliphase Ti8O15 nanoparticles fabricated by the arc-melting method exhibit >98% absorption of near infrared light and a superior photothermal therapy effect in the in vivo mouse model. The Ti8O15 nanoparticle PTT material also shows a good biocompatibility and biosafety. Our study reveals Magnéli-phase titanium oxide as a new family of PTT agents and introduces new applications of titanium oxides for photothermal conversion.
Tsinghua University Press
Gang Ou,Zhiwei Li,Dongke Li,Liang Cheng,Zhuang Liu,Hui Wu, Photothermal therapy by using titanium oxide nanoparticles. NanoRes.2016, 9(5): 1236–1243