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Nano Research

Article Title

Peptide recognition by functional supramolecular nanopores with complementary size and binding sites

Authors

Yumin Chen, State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China
Hui Nie, Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Hangzhou 310012, China
Ke Deng, CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China
Shili Wu, CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China
Jindong Xue, CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China
Lijin Shu, Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Hangzhou 310012, China
Yue Yu, CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China
Yanfang Geng, CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China
Ping Li, CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China
Yanlian Yang, CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China
Qingdao Zeng, CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China

Keywords

host–guest recognition, nanopore-confined, scanning tunnelingmicroscopy, shape-persistent macrocycle, supramolecular assembly

Abstract

The precise control of the conformations of biomolecules adsorbed on a surfaceat the single-molecule level is significant. However, it remains a huge challengebecause of the complex structure and conformation diversity of biomolecules.Herein, a “nanopore-confined recognition” strategy is proposed to manipulatethe adsorption of individual valinomycin molecules at room temperature throughprecise design of functionalized conjugated macrocycle (CPN8) supramolecularnanopores with complementary architectures and binding sites. We revealedthat CPN8 prefers to selectively recognizing valinomycin with complementaryarchitecture because of the strong synergistic interactions between the isopropylgroups of valinomycin and the amino groups of CPN8, with valinomycinhighlyoriented pyrolytic graphite (HOPG) interactions. Our perspectives at thesingle-molecule level will provide valuable insights to improve the design ofsupramolecular nanopores for conformation-selective recognition of non-conjugatedmolecules.

Graphical Abstract

Publisher

Tsinghua University Press

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