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Nano Research

Article Title

Precise synthesis of discrete and dispersible carbon-protected magnetic nanoparticles for efficient magnetic resonance imaging and photothermal therapy

Keywords

magnetic nanoparticles, carbon, Fe3O4, magnetic resonance imaging (MRI), colloidal suspensions, photothermal therapy

Abstract

Carbon-protected magnetic nanoparticles exhibit long-term stability in acid or alkaline medium, good biocompatibility, and high saturation magnetization. As a result, they hold great promise for magnetic resonance imaging, photothermal therapy, etc. However, since pyrolysis, which is often required to convert the carbon precursors to carbon, typically leads to coalescence of the nanoparticles, the obtained carbon-protected magnetic nanoparticles are usually sintered as a non-dispersible aggregation. We have successfully synthesized discrete, dispersible, and uniform carbon-protected magnetic nanoparticles via a precise surface/interface nano-engineering approach. Remarkably, the nanoparticles possess excellent water-dispersibility, biocompatibility, a high T2 relaxivity coefficient (384 mM–1·s–1), and a high photothermal heating effect. Furthermore, they can be used as multifunctional core components suited for future extended investigation in early diagnosis, detection and therapy, catalysis, separation, and magnetism. Nano Research DOI 10.1007/s12274-016-1042-9 Address correspondence to An-Hui Lu, anhuilu@dlut.edu.cn; Yan Zhang, zhangyanmed@126.com; Ferdi Schüth, schueth@mpi-muelheim.mpg.de

Graphical Abstract

Publisher

Tsinghua University Press

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