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Nano Research

Article Title

Multifunctional lymph-targeted platform based on Mn@mSiO2 nanocomposites: Combining PFOB for dual-mode imaging and DOX for cancer diagnose and treatment

Authors

Tian Liu, Country School of Materials Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China National Engineering Research Center for Nanotechnology, 28 East Jiang Chuan Road, Shanghai 200241, China
Guangyu Wu, Department of Radiology, Shanghai Renji Hospital, Shanghai Jiao Tong University School of Medicine, 1630 Dong Fang Rd, Shanghai200127, China
Jiejun Cheng, Department of Radiology, Shanghai Renji Hospital, Shanghai Jiao Tong University School of Medicine, 1630 Dong Fang Rd, Shanghai200127, China
Qing Lu, Department of Radiology, Shanghai Renji Hospital, Shanghai Jiao Tong University School of Medicine, 1630 Dong Fang Rd, Shanghai200127, China
Yanjie Yao, Country School of Materials Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China National Engineering Research Center for Nanotechnology, 28 East Jiang Chuan Road, Shanghai 200241, China
Zhenjing Liu, Country School of Materials Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
Dongchen Zhu, Country School of Materials Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
Juan Zhou, National Engineering Research Center for Nanotechnology, 28 East Jiang Chuan Road, Shanghai 200241, China
Jianrong Xu, Department of Radiology, Shanghai Renji Hospital, Shanghai Jiao Tong University School of Medicine, 1630 Dong Fang Rd, Shanghai200127, China
Jun Zhu, National Engineering Research Center for Nanotechnology, 28 East Jiang Chuan Road, Shanghai 200241, China
Dannong He, Country School of Materials Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China

Keywords

multifunctional platform, dual-mode imaging, magnetic resonance imaging (MRI), ultrasound imaging, cancer diagnosis

Abstract

ABSTRACT A universal platform with Mn doping and hyaluronic acid (HA) modification, based on mesoporous silica (mSiO2), was designed and used as a basic multifunctional material with magnetic resonance (MR) imaging. Furthermore, we added flexible functions through the addition of functional molecules. Specially, two typical compounds, hydrophobic perfluorooctyl bromide (PFOB) and hydrophilic doxorubicin (DOX), were loaded into the channels to obtain PFOB@Mn@mSiO2@HA (PMMH) or DOX@Mn@mSiO2@HA (DMMH) nanoparticles for dual-mode imaging or imaging and therapy, respectively. The PMMH and DMMH nanoparticles were highly targeted to the lymph system in vitro and in vivo. MR and ultrasound imaging of PMMH nanoparticles were performed in the lymph system, while MR imaging and chemotherapy of DMMH nanoparticles was used to detect cancer. These results showed that both PMMH and DMMH nanoparticles can be designed with high lymph targeting efficiency. PMMH nanoparticles are a dual-mode contrast agent for both ultrasound and MR imaging for the lymph system and DMMH nanoparticles are powerful agents for the combined diagnosis and therapy of cancer in vivo.

Graphical Abstract

Publisher

Tsinghua University Press

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