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Nano Research

Article Title

Gold nanoflowers for 3D volumetric molecular imaging of tumors by photoacoustic tomography

Authors

Yuanyuan Jiang, Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
Zijian Deng, Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China
Dan Yang, Single-molecule and Nanobiology Laboratory, Department of Biophysics, School of Basic Medical Sciences, and Biomed-X Center, Peking University, Beijing 100191, China
Xin Deng, Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
Qi Li, Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
Yinlin Sha, Single-molecule and Nanobiology Laboratory, Department of Biophysics, School of Basic Medical Sciences, and Biomed-X Center, Peking University, Beijing 100191, China
Changhui Li, Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China
Dongsheng Xu, Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China

Keywords

nanoparticles, gold nanoflowers, contrast agents, photoacoustic tomography, tumor imaging, molecular imaging

Abstract

By binding molecular probes that target tumor cells, gold nanoparticles (AuNPs) with superior characteristics have shown great potential in tumor molecular imaging studies. The non-invasive, high-resolution, and three-dimensional imaging of the targeted AuNPs within the tumor is desirable for both diagnosis and therapy. In this study, gold nanoflowers (AuNFs) are presented as a novel contrast agent for photoacoustic tomography (PAT). By binding to folic acid, the molecular probe, the tail-vein injected AuNFs concentrated within the tumor site in mice; this was clearly visualized by three-dimensional (3D) PAT imaging. In addition, toxicity assay proved that AuNFs were harmless to living cells and animals. Our results demonstrate that AuNFs have great potential in tumor molecular imaging.

Graphical Abstract

Publisher

Tsinghua University Press

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