Multifunctional electrospinning composite fibers for orthotopic cancer treatment in vivo
electrospinning orthotopic, treatment, controlled release, multiple structure
A multifunctional, dual-drug carrier platform was successfully constructed. Core-shell structured NaGdF4:Yb/Er@NaGdF4:Yb@mSiO2-polyethylene glycol (abbreviated as UCNPS) nanoparticles loadedwith the antitumor drug, doxorubicin (DOX) were incorporated into poly(ε-caprolactone) (PCL) and gelatin loaded with antiphlogistic drug, indomethacin (MC) to form nanofibrous fabrics (labeled as MC/UCNPS/DOX) via electrospinning process. The resultant multifunctional spinning pieces can be surgically implanted directly at the tumor site of mice as an orthotopic chemotherapy by controlled-release DOX from mesoporous silicon dioxide (SiO2) and upconversion fluorescence/magnetic resonance dual-model imaging through NaGdF4:Yb/Er@NaGdF4:Yb embedded in MC/UCNPS/DOX in vivo.
Tsinghua University Press
Yinyin Chen,Shi Liu,Zhiyao Hou,Pingan Ma,Dongmei Yang,Chunxia Li,Jun Lin, Multifunctional electrospinning composite fibers for orthotopic cancer treatment in vivo. NanoRes.2015, 8(6): 1917–1931