Novel carbon nanohybrids as highly efficient magnetic resonance imaging contrast agents
graphene oxide, metallofullerene, magnetic resonance imaging (MRI), nanohybrids
Novel carbon nanohybrids based on unmodified metallofullerenes have been successfully fabricated for use as a new magnetic resonance imaging (MRI) contrast agent. The nanohybrids showed higher R1relaxivity and better brightening effect than Gd@C82(OH)X, in T1-weighted MR images in vivo. This is a result of the proton relaxivity from the original gadofullerenes, which retained a perfect carbon cage structure and so might completely avoid the release of Gd3+ ions. A “secondary spin-electron transfer” relaxation mechanism was proposed to explain how the encaged Gd3+ ions of carbon nanohybrids interact with the surrounding water molecules. This approach opens new opportunities for developing highly efficient and low toxicity MRI contrast agents.
Tsinghua University Press
Rongli Cui,Juan Li,Huan Huang,Mingyi Zhang,Xihong Guo,Yanan Chang,Min Li,Jinquan Dong,Baoyun Sun,Gengmei Xing, Novel carbon nanohybrids as highly efficient magnetic resonance imaging contrast agents. NanoRes.2015, 8(4): 1259–1268