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Nano Research

Article Title

Smart Cu1.75S nanocapsules with high and stable photothermal efficiency for NIR photo-triggered drug release

Authors

Sheng Huang, State Key Laboratory of Chemical Resource Engineering, Beijing Key Laboratory of Environmentally Harmful Chemical Analysis, BeijingUniversity of Chemical Technology, Beijing 100029, China
Jing Liu, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of Chinaand Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100190, China
Qian He, State Key Laboratory of Chemical Resource Engineering, Beijing Key Laboratory of Environmentally Harmful Chemical Analysis, BeijingUniversity of Chemical Technology, Beijing 100029, China
Hongli Chen, State Key Laboratory of Chemical Resource Engineering, Beijing Key Laboratory of Environmentally Harmful Chemical Analysis, BeijingUniversity of Chemical Technology, Beijing 100029, China
Jiabin Cui, State Key Laboratory of Chemical Resource Engineering, Beijing Key Laboratory of Environmentally Harmful Chemical Analysis, BeijingUniversity of Chemical Technology, Beijing 100029, China
Suying Xu, State Key Laboratory of Chemical Resource Engineering, Beijing Key Laboratory of Environmentally Harmful Chemical Analysis, BeijingUniversity of Chemical Technology, Beijing 100029, China
Yuliang Zhao, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of Chinaand Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100190, China
Chunying Chen, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of Chinaand Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100190, China
Leyu Wang, State Key Laboratory of Chemical Resource Engineering, Beijing Key Laboratory of Environmentally Harmful Chemical Analysis, BeijingUniversity of Chemical Technology, Beijing 100029, China

Keywords

copper sulfides, near infrared light, photothermal therapy, drug release

Abstract

Thermosensitive drug delivery systems (DDSs) face major challenges, such as remote and repeatable control of in vivo temperature, although these can increase the therapeutic efficacy of drugs. To address this issue, we coated near- infrared (NIR) photothermal Cu1.75S nanocrystals with pH/thermos-sensitive polymer by in situ polymerization. The doxorubicine (DOX) loading content was up to 40 wt.%, with less than 8.2 wt.% of DOX being leaked under normal physiological conditions (pH = 7.4, 37 °C) for almost 48 h in the absence of NIR light. These nanocapsules demonstrate excellent photothermal stability by continuous longterm NIR irradiation. Based on the stable and high photothermal efficiency (55.8%), pre-loaded drugs were released as desired using 808-nm light as a trigger. Both in vitro and in vivo antitumor therapy results demonstrated that this smart nanoplatform is an effective agent for synergistic hyperthermia-based chemotherapy of cancer, demonstrating remote and noninvasive control.

Graphical Abstract

Publisher

Tsinghua University Press

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