
Article Title
Stable metallic 1T-WS2 ultrathin nanosheets as a promising agent for near-infrared photothermal ablation cancer therapy
Keywords
hydrothermal, ammonium ion-intercalated 1T-WS2, ultrathin nanosheets, biocompatibility, photostability, photothermal therapy
Abstract
In this study, we present the preparation of stable 1T-WS2 ultrathin nanosheets with NH4 + intercalation using a bottom-up hydrothermal method and the potential application of this material in light-induced photothermal cancer therapy. Our results revealed that nanosheets with a size of 150 nm were highly hydrophilic and exhibited strong light absorption and excellent photostability in the broad near-infrared wavelength region. The in vitro experimental results indicated good biocompatibility of the nanosheets. More notably, our in vivo antitumor experiments illustrated that light-induced photothermal ablation originating from irradiation of the 1T-WS2 nanosheets with an 808 nm laser could efficiently kill tumor cells; these effects were obtained not only at the cellular level but also in the living organs of mice. This result may lead to new applications of two-dimensional layered materials in novel photothermal therapies and other photothermal related fields.
Graphical Abstract
Publisher
Tsinghua University Press
Recommended Citation
Qin Liu,Chunyang Sun,Qun He,Adnan Khalil,Ting Xiang,Daobin Liu,Yu Zhou,Jun Wang,Li Song, Stable metallic 1T-WS2 ultrathin nanosheets as a promising agent for near-infrared photothermal ablation cancer therapy. NanoRes.2015, 8(12): 3982–3991