Article Title

Stable metallic 1T-WS₂ ultrathin nanosheets as a promising agent for near-infrared photothermal ablation cancer therapy

Authors

Qin Liu, National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei 230029, China
Chunyang Sun, Hefei National Laboratory for Physical Science at the Microscale, School of Life Sciences, University of Science and Technology of China,Hefei 230027, China
Qun He, National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei 230029, China
Adnan Khalil, National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei 230029, China
Ting Xiang, National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei 230029, China
Daobin Liu, National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei 230029, China
Yu Zhou, National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei 230029, China
Jun Wang, Hefei National Laboratory for Physical Science at the Microscale, School of Life Sciences, University of Science and Technology of China,Hefei 230027, China
Li Song, National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei 230029, China

Keywords

hydrothermal, ammonium ion-intercalated 1T-WS2, ultrathin nanosheets, biocompatibility, photostability, photothermal therapy

Abstract

In this study, we present the preparation of stable 1T-WS2 ultrathin nanosheets with NH4 + intercalation using a bottom-up hydrothermal method and the potential application of this material in light-induced photothermal cancer therapy. Our results revealed that nanosheets with a size of 150 nm were highly hydrophilic and exhibited strong light absorption and excellent photostability in the broad near-infrared wavelength region. The in vitro experimental results indicated good biocompatibility of the nanosheets. More notably, our in vivo antitumor experiments illustrated that light-induced photothermal ablation originating from irradiation of the 1T-WS2 nanosheets with an 808 nm laser could efficiently kill tumor cells; these effects were obtained not only at the cellular level but also in the living organs of mice. This result may lead to new applications of two-dimensional layered materials in novel photothermal therapies and other photothermal related fields.

Graphical Abstract

DOI

https://doi.org/10.1007/s12274-015-0901-0

Publisher

Tsinghua University Press

Recommended Citation

Qin Liu,Chunyang Sun,Qun He,Adnan Khalil,Ting Xiang,Daobin Liu,Yu Zhou,Jun Wang,Li Song, Stable metallic 1T-WS2 ultrathin nanosheets as a promising agent for near-infrared photothermal ablation cancer therapy. NanoRes.2015, 8(12): 3982–3991