Inhibitory activity of gold and silica nanospheres to vascular endothelial growth factor (VEGF)-mediated angiogenesis is determined by their sizes
nanospheres, anti-angiogenesis effects, inorganic nanoparticles, vascular endothelial growth factor, pathological angiogenesis
Nanoparticles can be involved in biological activities such as apoptosis, angio- genesis, and oxidative stress by themselves. In particular, inorganic nanoparticles such as gold and silica nanoparticles are known to inhibit vascular endothelial growth factor (VEGF)-mediated pathological angiogenesis. In this study, we show that anti-angiogenic effect of inorganic nanospheres is determined by their sizes. We demonstrate that 20 nm size gold and silica nanospheres suppress VEGF-induced activation of VEGF receptor-2, in vitro angiogenesis, and in vivo pathological angiogenesis more efficiently than their 100 nm size counterparts. Our results suggest that modulation of the size of gold and silica nanospheres determines their inhibitory activity to VEGF-mediated angiogenesis.
Tsinghua University Press
Dong Hyun Jo,Jin Hyoung Kim,Jin Gyeong Son,Yuanze Piao,Tae Geol Lee,Jeong Hun Kim, Inhibitory activity of gold and silica nanospheres to vascular endothelial growth factor (VEGF)-mediated angiogenesis is determined by their sizes. NanoRes.2014, 7(6): 844–852