Article Title

Inhibitory activity of gold and silica nanospheres to vascular endothelial growth factor (VEGF)-mediated angiogenesis is determined by their sizes

Authors

Dong Hyun Jo, Fight against Angiogenesis-Related Blindness (FARB) Laboratory, Clinical Research Institute, Seoul National University, Seoul, 110-744, Republic of Korea Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul, 110-799, Republic of Korea
Jin Hyoung Kim, Fight against Angiogenesis-Related Blindness (FARB) Laboratory, Clinical Research Institute, Seoul National University, Seoul, 110-744, Republic of Korea
Jin Gyeong Son, Center for Nano-Bio Convergence, World Class Laboratory, Korea Research Institute of Standards and Science, Daejeon, 305-340, Republic of Korea Department of Chemistry and KI for the NanoCentury, KAIST, Daejeon, 305-701, Republic of Korea
Yuanze Piao, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 151-742 & Advanced Institutes of Convergence Technology, Suwon 443-270, Republic of Korea
Tae Geol Lee, Center for Nano-Bio Convergence, World Class Laboratory, Korea Research Institute of Standards and Science, Daejeon, 305-340, Republic of Korea
Jeong Hun Kim, Fight against Angiogenesis-Related Blindness (FARB) Laboratory, Clinical Research Institute, Seoul National University, Seoul, 110-744, Republic of Korea Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul, 110-799, Republic of Korea Department of Ophthalmology, College of Medicine, Seoul National University, Seoul, 110-744, Republic of Korea

Keywords

nanospheres, anti-angiogenesis effects, inorganic nanoparticles, vascular endothelial growth factor, pathological angiogenesis

Abstract

Nanoparticles can be involved in biological activities such as apoptosis, angio- genesis, and oxidative stress by themselves. In particular, inorganic nanoparticles such as gold and silica nanoparticles are known to inhibit vascular endothelial growth factor (VEGF)-mediated pathological angiogenesis. In this study, we show that anti-angiogenic effect of inorganic nanospheres is determined by their sizes. We demonstrate that 20 nm size gold and silica nanospheres suppress VEGF-induced activation of VEGF receptor-2, in vitro angiogenesis, and in vivo pathological angiogenesis more efficiently than their 100 nm size counterparts. Our results suggest that modulation of the size of gold and silica nanospheres determines their inhibitory activity to VEGF-mediated angiogenesis.

Graphical Abstract

DOI

https://doi.org/10.1007/s12274-014-0445-8

Publisher

Tsinghua University Press

Recommended Citation

Dong Hyun Jo,Jin Hyoung Kim,Jin Gyeong Son,Yuanze Piao,Tae Geol Lee,Jeong Hun Kim, Inhibitory activity of gold and silica nanospheres to vascular endothelial growth factor (VEGF)-mediated angiogenesis is determined by their sizes. NanoRes.2014, 7(6): 844–852