"Glyconanomaterials: Emerging applications in biomedical research" by Xuan Chen, Olof Ramstrm et al.

Article Title

Glyconanomaterials: Emerging applications in biomedical research

Authors

Xuan Chen, Department of Chemistry, University of Massachusetts Lowell, Lowell, MA 01854, USA
Olof Ramstrm, Department of Chemistry, KTH—Royal Institute of Technology, Stockholm S-10044, Sweden
Mingdi Yan, Department of Chemistry, University of Massachusetts Lowell, Lowell, MA 01854, USA Department of Chemistry, KTH—Royal Institute of Technology, Stockholm S-10044, Sweden

Keywords

glyconanomaterials, carbohydrates, imaging, therapy

Abstract

Carbohydrates constitute the most abundant organic matter in nature, serving as structural components and energy sources, and mediating a wide range of cellular activities. The emergence of nanomaterials with distinct optical, magnetic, and electronic properties has witnessed a rapid adoption of these materials for biomedical research and applications. Nanomaterials of various shapes and sizes having large specific surface areas can be used as multivalent scaffolds to present carbohydrate ligands. The resulting glyconanomaterials effectively amplify the glycan-mediated interactions, making it possible to use these materials for sensing, imaging, diagnosis, and therapy. In this review, we summarize the synthetic strategies for the preparation of various glyconanomaterials. Examples are given where these glyconanomaterials have been used in sensing and differentiation of proteins and cells, as well as in imaging glycan-medicated cellular responses.