Article Title

Lithographically directed assembly of one-dimensional DNA nanostructures via bivalent binding interactions

Authors

Risheng Wang, Department of Applied Physics and Applied Mathematics, Columbia University, 500 West 120th Street, New York, NY 10027, USA Department of Chemistry, Columbia University, 500 West 120th Street, New York, NY 10027, USA
Matteo Palma, Department of Applied Physics and Applied Mathematics, Columbia University, 500 West 120th Street, New York, NY 10027, USA
Erika Penzo, Department of Applied Physics and Applied Mathematics, Columbia University, 500 West 120th Street, New York, NY 10027, USA
Shalom J. Wind, Department of Applied Physics and Applied Mathematics, Columbia University, 500 West 120th Street, New York, NY 10027, USA

Keywords

directed assembly, bivalent interactions, DNA nanostructures, 1D nanostructures

Abstract

ABSTRACT In order to exploit the outstanding physical properties of one-dimensional (1D) nanostructures such as carbon nanotubes and semiconducting nanowires and nanorods in future technological applications, it will be necessary to organize them on surfaces with precise control over both position and orientation. Here, we use a 1D rigid DNA motif as a model for studying directed assembly at the molecular scale to lithographically patterned nanodot anchors. By matching the inter-nanodot spacing to the length of the DNA nanostructure, we are able to achieve nearly 100% placement yield. By varying the length of single-stranded DNA linkers bound covalently to the nanodots, we are able to study the binding selectivity as a function of the strength of the binding interactions. We analyze the binding in terms of a thermodynamic model which provides insight into the bivalent nature of the binding, a scheme that has general applicability for the controlled assembly of a broad range of functional nanostructures.

Graphical Abstract

DOI

https://doi.org/10.1007/s12274-013-0318-6

Publisher

Tsinghua University Press

Recommended Citation

Risheng Wang,Matteo Palma,Erika Penzo,Shalom J. Wind, Lithographically directed assembly of one-dimensional DNA nanostructures via bivalent binding interactions. NanoRes.2013, 6(6): 409–417