Nano Research

Article Title

A perspective on functionalizing colloidal quantum dots with DNA


colloidal quantum dots, semiconductor nanocrystals, DNA, conjugation, ligand exchange, covalent bond, core/shell


ABSTRACT This perspective provides an overview of the techniques that have been developed for the conjugation of DNA to colloidal quantum dots (QDs), or semiconductor nanocrystals. Methods described include: ligand exchange at the QD surface, covalent conjugation of DNA to the QD surface ligands, and one-step DNA functionalization on core QDs or during core/shell QD synthesis in aqueous solution, with an emphasis on the most recent progress in our lab. We will also discuss emerging trends in DNA-functionalized QDs for potential applications.

Graphical Abstract


Tsinghua University Press