Hollow iron oxide nanoparticles as multidrug resistant drug delivery and imaging vehicles
drug resistance, hollow nanoparticles, doxorubicin, magnetic resonance imaging (MRI), drug delivery
ABSTRACT Magnetic nanoparticles have been used as drug delivery vehicles against a number of cancer cells. Most of these theranostic formulations have used solid iron oxide nanoparticles (SIONPs) loaded with chemotherapeutics as nano-carrier formulation for both magnetic resonance imaging (MRI) and cancer therapy. In this study, we applied the dopamine-plus-human serum albumin (HSA) method to modify hollow iron oxide nanoparticles (HIONPs) and encapsuated doxorubicin (DOX) within the hollow porous structure of the nano-carrier. The new delivery system can load more drug than solid iron oxide nanoparticles of the same core size using the same coating strategy. The HIONPs–DOX formulation also has a pH-dependent drug release behaviour. Compared with free DOX, the HIONPs–DOX were more effectively uptaken by the multidrug resistant OVCAR8- ADR cells and consequently more potent in killing drug resistant cancer cells. MRI phantom and cell studies also showed that the HIONPs–DOX can decrease the T2 MRI signal intensity and can be used as a MRI contrast agent while acting as a drug delivery vehicle. For the first time, the dual application of chemo drug transport and MR imaging using the HIONPs–DOX formulation was achieved against both DOX-sensitive and DOX-resistant cancer cells.
Tsinghua University Press
Ruijun Xing,Ashwinkumar A. Bhirde,Shouju Wang,Xiaolian Sun,Gang Liu,Yanglong Hou,Xiaoyuan Chen, Hollow iron oxide nanoparticles as multidrug resistant drug delivery and imaging vehicles. NanoRes.2013, 6(1): 1–9