Article Title

A functionalized graphene oxide-iron oxide nanocomposite for magnetically targeted drug delivery, photothermal therapy, and magnetic resonance imaging

Authors

Xinxing Ma, Department of Radiology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials Laboratory (FUNSOM), Soochow University, Suzhou, Jiangsu 215123, China
Huiquan Tao, Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials Laboratory (FUNSOM), Soochow University, Suzhou, Jiangsu 215123, China
Kai Yang, Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials Laboratory (FUNSOM), Soochow University, Suzhou, Jiangsu 215123, China
Liangzhu Feng, Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials Laboratory (FUNSOM), Soochow University, Suzhou, Jiangsu 215123, China
Liang Cheng, Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials Laboratory (FUNSOM), Soochow University, Suzhou, Jiangsu 215123, China
Xiaoze Shi, Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials Laboratory (FUNSOM), Soochow University, Suzhou, Jiangsu 215123, China
Yonggang Li, Department of Radiology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China
Liang Guo, Department of Radiology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China
Zhuang Liu, Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials Laboratory (FUNSOM), Soochow University, Suzhou, Jiangsu 215123, China

Keywords

Graphene oxide, magnetic nanocomposite, magnetic targeting, drug delivery, photothermal therapy, magnetic resonance imaging

Abstract

Two-dimensional graphene and its composite nanomaterials offer interesting physical/chemical properties and have been extensively explored in a wide range of fields in recent years. In this work, we synthesize a multifunctional superparamagnetic graphene oxide–iron oxide hybrid nanocomposite (GO–IONP), which is then functionalized by a biocompatible polyethylene glycol (PEG) polymer to acquire high stability in physiological solutions. A chemotherapy drug, doxorubicin (DOX), was loaded onto GO–IONP–PEG, forming a GO–IONP– PEG–DOX complex, which enables magnetically targeted drug delivery. GO–IONP–PEG also exhibits strong optical absorbance from the visible to the near-infrared (NIR) region, and can be utilized for localized photothermal ablation of cancer cells guided by the magnetic field. Moreover, for the first time, in vivo magnetic resonance (MR) imaging of tumor-bearing mice is also demonstrated using GO–IONP–PEG as the T2 contrast agent. Our work suggests the promise of using multifunctional GO-based nanocomposites for applications in cancer theranostics.

Graphical Abstract

DOI

https://doi.org/10.1007/s12274-012-0200-y

Publisher

Tsinghua University Press

Recommended Citation

Xinxing Ma,Huiquan Tao,Kai Yang,Liangzhu Feng,Liang Cheng,Xiaoze Shi,Yonggang Li,Liang Guo,Zhuang Liu, A functionalized graphene oxide-iron oxide nanocomposite for magnetically targeted drug delivery, photothermal therapy, and magnetic resonance imaging. NanoRes.2012, 5(3): 199–212