Nano Research

Article Title

Movable Au microplates as fluorescence enhancing substrates for live cells


Au microplates, synthesis, cell substrate, metal enhanced fluorescence, manipulation


Hexagonal and triangular Au microplates extending over an area of ~12,000 µm2 with thickness in the range 30–1000 nm have been synthesized using a single step thermolysis of (AuCl4)– –tetraoctylammonium bromide complex in air. The microplates are self-supporting and can be easily manipulated using a sharp pin, a property which enables them to serve as substrates for living cells. The microplate surface is non-toxic to living cells and can enhance the fluorescence signal from fluorophores residing within the cell by an order of magnitude. In addition, the microplates are smooth and single-crystalline, and ideal as microscopy substrates and molecular electrodes. The growth of the microplates in the initial stages is interesting in that they seem to grow perpendicular to the substrate, as evidenced by in situ microscopy.

Graphical Abstract


Tsinghua University Press