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Nano Research

Article Title

Metabolic profile of chiral cobalt oxide nanoparticles in vitro and in vivo

Authors

Si Li, International Joint Research Laboratory for Biointerface and Biodetection, Jiangnan University, Wuxi 214122, China; State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China
Liwei Xu, International Joint Research Laboratory for Biointerface and Biodetection, Jiangnan University, Wuxi 214122, China; State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China
Meiru Lu, International Joint Research Laboratory for Biointerface and Biodetection, Jiangnan University, Wuxi 214122, China; State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China
Maozhong Sun, International Joint Research Laboratory for Biointerface and Biodetection, Jiangnan University, Wuxi 214122, China; State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China
Liguang Xu, International Joint Research Laboratory for Biointerface and Biodetection, Jiangnan University, Wuxi 214122, China; State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China
Changlong Hao, International Joint Research Laboratory for Biointerface and Biodetection, Jiangnan University, Wuxi 214122, China; State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaFollow
Xiaoling Wu, International Joint Research Laboratory for Biointerface and Biodetection, Jiangnan University, Wuxi 214122, China; State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaFollow
Chuanlai Xu, International Joint Research Laboratory for Biointerface and Biodetection, Jiangnan University, Wuxi 214122, China; State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaFollow
Hua Kuang, International Joint Research Laboratory for Biointerface and Biodetection, Jiangnan University, Wuxi 214122, China; State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China

Keywords

chiral metal oxide, endocytosis, bile acid, metabolism

Abstract

In this study, we investigated the in vivo behaviors of chiral cobalt oxide nanoparticles (Co3O4 NPs) stabilized with D- or L-cysteine (denoted D- or L-NPs, respectively), as representative chiral metal oxide NPs. Chiral Co3O4 NPs exerted no observable cytotoxicity within the tested dose range. Both D-NPs and L-NPs were internalized by dendritic cells through caveola-dependent endocytosis, and L-NPs entered the cells faster than D-NPs. Significantly, a metabolic analysis indicated that chiral L-NPs had the same effect on the level of bile acids in the liver as D-NPs, which is attributed to the almost equal amount of farnesoid X receptor (FXR) induced by the chiral NPs. This study suggests that low chiroptical activity nanomaterials would not affect the metabolism and kinetics under physiological conditions even if there is some difference in their transport.

Publisher

Tsinghua University Press

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