•  
  •  
 
Nano Research

Article Title

Cyanobacteria-based near-infrared light-excited self-supplying oxygen system for enhanced photodynamic therapy of hypoxic tumors

Authors

Yinghua Zhang, College of Chemistry & Environmental Science, Analytical Chemistry Key Laboratory of Hebei Province, Chemical Biology Key Laboratory of Hebei Province, Hebei University, Baoding 071002, China;Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Institute of Life Science and Green Development, Hebei University, Baoding 071002, China
Huifang Liu, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Institute of Life Science and Green Development, Hebei University, Baoding 071002, China;College of Pharmaceutical Science, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding 071002, China
Xinyue Dai, College of Chemistry & Environmental Science, Analytical Chemistry Key Laboratory of Hebei Province, Chemical Biology Key Laboratory of Hebei Province, Hebei University, Baoding 071002, China;Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Institute of Life Science and Green Development, Hebei University, Baoding 071002, China
Hang Li, College of Chemistry & Environmental Science, Analytical Chemistry Key Laboratory of Hebei Province, Chemical Biology Key Laboratory of Hebei Province, Hebei University, Baoding 071002, China;Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Institute of Life Science and Green Development, Hebei University, Baoding 071002, China
Xiaohan Zhou, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Institute of Life Science and Green Development, Hebei University, Baoding 071002, China
Shizhu Chen, Beijing Pharmaceutical Group Company Limited, Beijing 100101, China;The National Institutes of Pharmaceutical R&D Co., Ltd., China Resources Pharmaceutical Group Limited, Beijing 102206, China
Jinchao Zhang, College of Chemistry & Environmental Science, Analytical Chemistry Key Laboratory of Hebei Province, Chemical Biology Key Laboratory of Hebei Province, Hebei University, Baoding 071002, China;Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Institute of Life Science and Green Development, Hebei University, Baoding 071002, China
Xing-Jie Liang, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Institute of Life Science and Green Development, Hebei University, Baoding 071002, China;College of Pharmaceutical Science, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding 071002, China;CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China
Zhenhua Li, College of Chemistry & Environmental Science, Analytical Chemistry Key Laboratory of Hebei Province, Chemical Biology Key Laboratory of Hebei Province, Hebei University, Baoding 071002, China;Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Institute of Life Science and Green Development, Hebei University, Baoding 071002, China

Keywords

self-supplying oxygen, cyanobacteria, hypoxic tumor, photodynamic therapy, upconversion nanoparticles

Abstract

Tumor hypoxia has been considered to induce tumor cell resistance to radiotherapy and anticancer chemotherapy, as well as predisposing for increased tumor metastases. Therefore, strategies for the eradication of the hypoxic tumor are highly desirable. Photodynamic therapy (PDT) is a new technique that can be used to treat tumors using laser irradiation to photochemically activate a photosensitizer. Compared to traditional radiotherapy and chemotherapy, photodynamic therapy has many advantages, such as good selectivity, low toxicity, and less trauma and resistance. However, PDT is oxygen-dependent, and the lack of oxygen in hypoxic tumors renders photodynamic therapy ineffective. Cyanobacteria, the earliest photosynthetic oxygen-generating organisms, can utilize water as an electron donor to reduce CO2 into organic carbon compounds along with continuously releasing oxygen under sunlight. Inspired by this, herein, cyanobacteria were used as a living carrier of photosensitizer conjugated upconversion nanoparticles (UCNP) to construct a self-supplying oxygen PDT system. Improvement in the PDT efficiency for hypoxic tumors can be achieved as a result of in situ oxygen production by cyanobacteria under near-infrared (NIR) light using UCNP as a light harvesting antenna. A successful demonstration of this concept would be of great significance and could open the door to a new generation of carrier systems in the field of hypoxia-targeted drug transport platforms.

Publisher

Tsinghua University Press

Share

COinS