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Nano Research

Article Title

Mesoporous silica rods with cone shaped pores modulate inflammation and deliver BMP-2 for bone regeneration

Authors

Chun Xu, School of Dentistry, The University of Queensland, Herston, QLD, 4006, Australia Center for Minimally Invasive Therapeutics (C-MIT), University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA Department of Bioengineering, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA
Lan Xiao, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove Campus, Brisbane, 4006, Australia
Yuxue Cao, School of Dentistry, The University of Queensland, Herston, QLD, 4006, Australia
Yan He, School of Dentistry, The University of Queensland, Herston, QLD, 4006, Australia School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325035, China Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital and Harvard School of Dental Medicine, Boston, MA 02114, USA
Chang Lei, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia
Yin Xiao, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove Campus, Brisbane, 4006, Australia
Wujin Sun, Center for Minimally Invasive Therapeutics (C-MIT), University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA Department of Bioengineering, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA
Samad Ahadian, Center for Minimally Invasive Therapeutics (C-MIT), University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA Department of Bioengineering, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA
Xueting Zhou, Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA
Ali Khademhosseini, Center for Minimally Invasive Therapeutics (C-MIT), University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA Department of Bioengineering, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA Department of Chemical and Biomolecular Engineering, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA Department of Radiological Sciences, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90095, USA
Qingsong Ye, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325035, China Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital and Harvard School of Dental Medicine, Boston, MA 02114, USA

Keywords

mesoporous silica rod, bone regeneration, cone shaped pores, morphogenetic proteins 2 (BMP-2) delivery, osteoimmunomodulation

Abstract

Biomaterials with suitable osteoimmunomodulation properties and ability to deliver osteoinductive biomolecules, such as bone morphogenetic proteins, are desired for bone regeneration. Herein, we report the development of mesoporous silica rods with large cone-shaped pores (MSR-CP) to load and deliver large protein drugs. It is noted that those cone-shaped pores on the surface modulated the immune response and reduced the pro-inflammatory reaction of stimulated macrophage. Furthermore, bone morphogenetic proteins 2 (BMP-2) loaded MSR-CP facilitated osteogenic differentiation and promoted osteogenesis of bone marrow stromal cells. In vivo tests confirmed BMP-2 loaded MSR-CP improved the bone regeneration performance. This study provides a potential strategy for the design of drug delivery systems for bone regeneration.

Graphical Abstract

Publisher

Tsinghua University Press

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