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Nano Research

Article Title

NIR-II driven plasmon-enhanced cascade reaction for tumor microenvironment-regulated catalytic therapy based on bio-breakable Au–Ag nanozyme

Authors

Min Xu, Tianjin Key Laboratory of Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China
Qianglan Lu, Tianjin Key Laboratory of Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China
Yiling Song, Tianjin Key Laboratory of Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China
Lifang Yang, Tianjin Key Laboratory of Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China
Chuchu Ren, Tianjin Key Laboratory of Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China
Wen Li, Tianjin Key Laboratory of Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China
Ping Liu, Tianjin Key Laboratory of Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China
Yule Wang, Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China Research and Development Center of TCM, Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China
Yan Zhu, Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China Research and Development Center of TCM, Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China
Nan Li, Tianjin Key Laboratory of Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China

Keywords

near-infrared (NIR)-II driven, plasmon-enhanced catalysis, Au–Ag hollow nanotriangles, bio-breakable, cascade reaction

Abstract

Emerging nanozymes with natural enzyme-mimicking catalytic activities have inspired extensive research interests due to their high stability, low cost, and simple preparation, especially in the field of catalytic tumor therapy. Here, bio-breakable nanozymes based on glucose-oxidase (GOx)-loaded biomimetic Au–Ag hollow nanotriangles (Au–Ag–GOx HTNs) are designed, and they trigger an near-infrared (NIR)-II-driven plasmon-enhanced cascade catalytic reaction through regulating tumor microenvironment (TME) for highly efficient tumor therapy. Firstly, GOx can effectively trigger the generation of gluconic acid (H+) and hydrogen peroxide (H2O2), thus depleting nutrients in the tumor cells as well as modifying TME to provide conditions for subsequent peroxidase (POD)-like activity. Secondly, NIR-II induced surface plasmon resonance can induce hot electrons to enhance the catalytic activity of Au–Ag–GOx HTNs, eventually boosting the generation of hydroxyl radicals (•OH). Interestingly, the generated H2O2 and H+ can simultaneously induce the degradation of Ag nanoprisms to break the intact triangle nanostructure, thus promoting the excretion of Au–Ag–GOx HTNs to avoid the potential risks of drug metabolism. Overall, the NIR-II driven plasmon-enhanced catalytic mechanism of this bio-breakable nanozyme provides a promising approach for the development of nanozymes in tumor therapy.

Graphical Abstract

Publisher

Tsinghua University Press

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