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Nano Research

Article Title

Recent advances in photodynamic therapy based on emerging two-dimensional layered nanomaterials

Authors

Xinqiang Wu, Department of Hepatobiliary Surgery, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China
Xiaofeng Jiang, Department of Hepatobiliary Surgery, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China
Taojian Fan, Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, Collaborative Innovation Centre for Optoelectronic Science & Technology, Institute of Microscale Optoelectronics, Shenzhen University, Shenzhen 518060, China College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China Shenzhen Key Laboratory of Micro-Nano Photonic Information Technology, Guangdong Laboratory of Artificial Intelligence and Digital Economy (SZ), Shenzhen University, Shenzhen 518060, China
Zhiwei Zheng, Department of Hepatobiliary Surgery, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China
Zhaoyuan Liu, Department of Hepatobiliary Surgery, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China
Yubin Chen, Department of Hepatobiliary Surgery, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China
Liangqi Cao, Department of Hepatobiliary Surgery, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China
Zhongjian Xie, Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, Collaborative Innovation Centre for Optoelectronic Science & Technology, Institute of Microscale Optoelectronics, Shenzhen University, Shenzhen 518060, China College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China Shenzhen Key Laboratory of Micro-Nano Photonic Information Technology, Guangdong Laboratory of Artificial Intelligence and Digital Economy (SZ), Shenzhen University, Shenzhen 518060, China
Dawei Zhang, Department of Hepatobiliary Surgery, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China
Jiaqi Zhao, Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, Collaborative Innovation Centre for Optoelectronic Science & Technology, Institute of Microscale Optoelectronics, Shenzhen University, Shenzhen 518060, China College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China Shenzhen Key Laboratory of Micro-Nano Photonic Information Technology, Guangdong Laboratory of Artificial Intelligence and Digital Economy (SZ), Shenzhen University, Shenzhen 518060, China
Qiwen Wang, Department of Hepatobiliary Surgery, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China
Zhenhui Huang, Department of Hepatobiliary Surgery, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China
Zhijian Chen, Department of Hepatobiliary Surgery, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China
Ping Xue, Department of Hepatobiliary Surgery, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China
Han Zhang, Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, Collaborative Innovation Centre for Optoelectronic Science & Technology, Institute of Microscale Optoelectronics, Shenzhen University, Shenzhen 518060, China College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China Shenzhen Key Laboratory of Micro-Nano Photonic Information Technology, Guangdong Laboratory of Artificial Intelligence and Digital Economy (SZ), Shenzhen University, Shenzhen 518060, China

Keywords

two-dimensional nanomaterials, photodynamic therapy, photosensitizer, reactive oxygen species

Abstract

Photodynamic therapy (PDT) is a promising non-invasive therapy approach for various diseases including malignant tumor. The process of PDT involves three interrelated aspects, namely photosensitizer (PS), light source, and oxygen, among which PS is the decisive factor that determines its anticancer efficiency. There exist some defects in currently applied PDT, such as inadequate production of reactive oxygen species (ROS), poor penetration of exciting light, insufficient oxygen supply, and nonselective distribution of PS. With unique physicochemical and optical properties, two-dimensional nanomaterials (2DNMs) have aroused great interest in biomedical fields. 2DNMs-based PDT is promising to significantly improve antitumor efficacy compared to conventional PDT. In this review, we will firstly introduce the underlying mechanism of PDT and how 2DNMs are absorbed and distribute inside tumor cells. After that, we will not only illustrate how 2DNMs-based PDT can enhance tumor-killing efficacy and minimize side-effects through conquering the above-mentioned defects of conventional PDT and the preparation process of 2DNMs, but also elaborate recent advances about 2DNMs-based PDT. Lastly, we will summarize the challenges and future prospects of 2DNMs-based PDT.

Graphical Abstract

Publisher

Tsinghua University Press

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