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Nano Research

Article Title

One-step synthesis of amine-coated ultra-small mesoporous silica nanoparticles

Authors

Mingyue Cui, Nanyang Environment & Water Research Institute, Interdisciplinary Graduate Programme, Nanyang Technological University, Singapore 637141, Singapore School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637457, Singapore
Christian Wiraja, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637457, Singapore
Lim Wei Qi, Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore
Sharon Chew Wan Ting, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637457, Singapore
Deblin Jana, Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore
Mengjia Zheng, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637457, Singapore
Xiao Hu, Nanyang Environment & Water Research Institute, Interdisciplinary Graduate Programme, Nanyang Technological University, Singapore 637141, Singapore School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore
Chenjie Xu, Nanyang Environment & Water Research Institute, Interdisciplinary Graduate Programme, Nanyang Technological University, Singapore 637141, Singapore School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637457, Singapore National Dental Centre of Singapore, 5 Second Hospital Ave, Singapore 168938, Singapore Department of Biomedical Engineering, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, China

Keywords

silica nanoparticles, one-step synthesis, surface modification, bacterial & cell labelling

Abstract

Silica nanoparticles have been studied extensively in biomedical field due to their high biocompatibility, controllable morphology and so on. They can be used both as the drug carrier and imaging vehicle. Here, an aminated ultra-small silica nanoparticle based system is developed with various functionalities. Multiple molecules including fluorophore, folic acid, and antibody are coupled to this system to achieve specific applications such as bacterial/cell labelling and recognition.

Graphical Abstract

Publisher

Tsinghua University Press

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