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Nano Research

Article Title

Super stable CsPbBr3@SiO2 tumor imaging reagent by stress-response encapsulation

Authors

Wentao Song, Eco-materials and Renewable Energy Research Center (ERERC), College of Engneering and Applied Sciences, Nanjing University, No. 22 Hankou Road, Nanjing 210093, China
Yiming Wang, Eco-materials and Renewable Energy Research Center (ERERC), College of Engneering and Applied Sciences, Nanjing University, No. 22 Hankou Road, Nanjing 210093, China
Bing Wang, Jiangsu Key Laboratory for Nano Technology, National Laboratory of Solid State Microstructures, Department of Physics, Nanjing University, No. 22 Hankou Road, Nanjing 210093, China Collaborative Innovation Center of Advanced Microstructures, Nanjing University, No. 22 Hankou Road, Nanjing 210093, China
Yingfang Yao, Eco-materials and Renewable Energy Research Center (ERERC), College of Engneering and Applied Sciences, Nanjing University, No. 22 Hankou Road, Nanjing 210093, China Jiangsu Key Laboratory for Nano Technology, National Laboratory of Solid State Microstructures, Department of Physics, Nanjing University, No. 22 Hankou Road, Nanjing 210093, China Collaborative Innovation Center of Advanced Microstructures, Nanjing University, No. 22 Hankou Road, Nanjing 210093, China
Wenguang Wang, Jiangsu Key Laboratory for Nano Technology, National Laboratory of Solid State Microstructures, Department of Physics, Nanjing University, No. 22 Hankou Road, Nanjing 210093, China
Jinhui Wu, Jiangsu Key Laboratory for Nano Technology, National Laboratory of Solid State Microstructures, Department of Physics, Nanjing University, No. 22 Hankou Road, Nanjing 210093, China
Qing Shen, Faculty of Informatics and Engineering, The University of Electro-Communications, Tokyo 182-8585, Japan
Wenjun Luo, Eco-materials and Renewable Energy Research Center (ERERC), College of Engneering and Applied Sciences, Nanjing University, No. 22 Hankou Road, Nanjing 210093, China Jiangsu Key Laboratory for Nano Technology, National Laboratory of Solid State Microstructures, Department of Physics, Nanjing University, No. 22 Hankou Road, Nanjing 210093, China Collaborative Innovation Center of Advanced Microstructures, Nanjing University, No. 22 Hankou Road, Nanjing 210093, China
Zhigang Zou, Eco-materials and Renewable Energy Research Center (ERERC), College of Engneering and Applied Sciences, Nanjing University, No. 22 Hankou Road, Nanjing 210093, China Jiangsu Key Laboratory for Nano Technology, National Laboratory of Solid State Microstructures, Department of Physics, Nanjing University, No. 22 Hankou Road, Nanjing 210093, China Collaborative Innovation Center of Advanced Microstructures, Nanjing University, No. 22 Hankou Road, Nanjing 210093, China Macau Institute of Systems Engineering, Macau University of Science and Technology, Macau 999078, China

Keywords

CsPbBr3 nanocrystals, stress response encapsulation, cancer diagnose

Abstract

Great photoelectric properties can herald the high potentials of CsPbBr3 nanocrystals (NCs) to function as the fluorescent probes for early tumor diagnosis. However, the intrinsic water vulnerability of CsPbBr3 NCs highly restricts their biomedical applications. To conquer this challenge, we herein introduce a nature inspired “stress-response” method to tightly encapsulate CsPbBr3 into SiO2 nano-shells that can dramatically improve the water stability of CsPbBr3@SiO2 nanoparticles for over 48 h. We further highlighted the advantageous features of CsPbBr3@SiO2 by using them as the fluorescent probes for CT26 tumor cell imaging with their high water stability, biocompatibility, and low cytotoxicity. Our work for the first time exhibited the potential of lead halide perovskite NCs for tumor diagnosis, and can highly anticipate the further in vivo biomedical applications that light up live cells.

Graphical Abstract

Publisher

Tsinghua University Press

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