•  
  •  
 
Nano Research

Article Title

Excipient-free porphyrin/SN-38 based nanotheranostics for drug delivery and cell imaging

Authors

Ye Yuan, Center for Smart Materials and Devices, State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China Department of Biochemistry and Molecular Medicine, UC Davis Comprehensive Cancer Center, University of California Davis, Sacramento 95817, USA
Ruonan Bo, Department of Biochemistry and Molecular Medicine, UC Davis Comprehensive Cancer Center, University of California Davis, Sacramento 95817, USA School of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China
Di Jing, Department of Biochemistry and Molecular Medicine, UC Davis Comprehensive Cancer Center, University of California Davis, Sacramento 95817, USA Department of Oncology, Xiangya Hospital, Central South University, Changsha 410008, China
Zhao Ma, Department of Biochemistry and Molecular Medicine, UC Davis Comprehensive Cancer Center, University of California Davis, Sacramento 95817, USA
Zhongling Wang, Department of Biochemistry and Molecular Medicine, UC Davis Comprehensive Cancer Center, University of California Davis, Sacramento 95817, USA Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China
Tzu-yin Lin, Division of Hematology/Oncology, Department of Internal Medicine, University of California Davis, Sacramento 95817, USA
Lijie Dong, Center for Smart Materials and Devices, State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China
Xiangdong Xue, Department of Biochemistry and Molecular Medicine, UC Davis Comprehensive Cancer Center, University of California Davis, Sacramento 95817, USA College of Life Sciences, Northwest University, Xi’an 710069, China
Yuanpei Li, Department of Biochemistry and Molecular Medicine, UC Davis Comprehensive Cancer Center, University of California Davis, Sacramento 95817, USA

Keywords

porphyrin, 7-ethyl-10-hydroxy-camptothecin (SN-38), drug delivery, self-indication, nanotheranostics, photodynamic therapy

Abstract

Nanotheranostics with comprehensive diagnostic and therapeutic capabilities show exciting cancer treatment potentials. Here, we develop an excipient-free drug delivery system for cancer diagnosis as well as therapy, in which a near infra-red photosensitizer and a chemotherapeutic drug can be self-delivered without any carriers. The building block of the drug delivery system was synthesized by covalently conjugating four anticancer drugs (7-ethyl-10-hydroxy-camptothecin, SN-38) with a photosensitizer (porphyrin) via hydrolyzable ester linkage, which endows the drug delivery system with 100% active pharmaceutical ingredients, excellent imaging, and therapeutic functionalities. The conjugates can readily self-assemble into nanosheets (PS NSs) and remain stable for at least 20 days in aqueous solution. In PS NSs, fluorescence resonance energy transfer (FRET) dominates the fluorescence of SN-38 and enables to monitor the drug release fluorescently. The PS NSs also show excellent anticancer activity in vitro, due to the increased cell uptake with the synergistic effect of photodynamic therapy and chemotherapy.

Graphical Abstract

Publisher

Tsinghua University Press

Share

COinS