•  
  •  
 
Nano Research

Article Title

Micro or nano: Evaluation of biosafety and biopotency of magnesium metal organic framework-74 with different particle sizes

Authors

Zhou Zhu, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
Shaokang Jiang, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
Yanhua Liu, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
Xiaomeng Gao, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
Shanshan Hu, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
Xin Zhang, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
Chao Huang, College of Chemistry, Sichuan University, Chengdu 610064, China
Qianbing Wan, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
Jian Wang, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
Xibo Pei, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China

Keywords

magnesium metal organic framework-74, micron/nanoscale, biological applications, osteogenesis, angiogenesis

Abstract

In recent years, various particulate materials have played important roles in medical applications. However, nano- and micron-sized particles of the same material could exhibit distinct properties due to different particle sizes. This finding provided a simple and effective way to improve the biological applications of particulate materials. Therefore, as a highly promising member, the effect of the particle size change of the magnesium metal organic framework-74 (Mg-MOF74) was well worth evaluating. Here we firstly assessed the in vitro and in vivo toxicity of micron/nanoscale Mg-MOF74 (m-Mg-MOF74/n-Mg-MOF74) in detail. Our in vitro study revealed that compared to micron-sized subjects, n-Mg-MOF74 provided a wider range of safe concentrations. Furthermore, both micron/nanoscale Mg-MOF74 showed good biocompatibility and allowed all the rats under the treatment to survive through the expected experimental periods, with n-Mg-MOF74 still showing lower cardiotoxicity. These advantages of nanoscale Mg-MOF74 might benefit from its sustainable and balanced release of Mg2+ both inside and outside the cells. Based on the biosafety evaluation, advanced bio-functional assessments of m/n-Mg-MOF74 including early osteogenesis and angiogenesis were also performed. Similarly, the suitable dose groups of n-Mg-MOF74 achieved optimal early osteogenic promotion and angiogenic stimulation effects. Overall, our combined data delineated the toxicity and biological behaviors of Mg-MOF74 of different scales, and suggested nanoscale Mg-MOF74 as a better choice for future applications. This result revealed that particle size reduction might be a viable strategy to improve and expand medical applications of MOFs or other particulate materials.

Graphical Abstract

Publisher

Tsinghua University Press

Share

COinS