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Nano Research

Article Title

Core-satellite metal-organic framework@upconversion nanoparticle superstructures via electrostatic self-assembly for efficient photodynamic theranostics

Authors

Zhike Li, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China
Xi Qiao, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China
Guihua He, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China
Xin Sun, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China
Danhua Feng, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China
Liefeng Hu, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China
Hua Xu, State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China
Hai-Bing Xu, Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, China
Shengqian Ma, Department of Chemistry, University of North Texas, Denton, TX 76201, USA
Jian Tian, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China

Keywords

core-satellite structures, upconversion nanoparticles (UCNPs), nanoscale metal-organic frameworks, photodynamic therapy, theranostics

Abstract

The nanoplatforms based on upconversion nanoparticles (UCNPs) have shown great promise in amplified photodynamic therapy (PDT) triggered by near-infrared (NIR) light. However, their practical in vivo applications are hindered by the overheating effect of 980 nm excitation and low utilization of upconversion luminescence (UCL) by photosensitizers. To solve these defects, core-satellite metal-organic framework@UCNP superstructures, composed of a single metal-organic framework (MOF) NP as the core and Nd3+-sensitized UCNPs as the satellites, are designed and synthesized via a facile electrostatic self-assembly strategy. The superstructures realize a high co-loading capacity of chlorin e6 (Ce6) and rose bengal (RB) benefitted from the highly porous nature of MOF NPs, showing a strong spectral overlap between maximum absorption of photosensitizers and emission of UCNPs. The in vitro and in vivo experiments demonstrate that the dual-photosensitizer superstructures have trimodal (magnetic resonance (MR)/UCL/fluorescence (FL)) imaging functions and excellent antitumor effectiveness of PDT at 808 nm NIR light excitation, avoiding the laser irradiation-induced overheating issue. This study provides new insights for the development of highly efficient PDT nanodrugs toward precision theranostics.

Publisher

Tsinghua University Press

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