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Nano Research

Article Title

iRGD decorated liposomes: A novel actively penetrating topical ocular drug delivery strategy

Authors

Hai Huang, Outpatient Department, Department of Critical Care Medicine, National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China
Xiaorong Yang, Outpatient Department, Department of Critical Care Medicine, National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China
Huili Li, Outpatient Department, Department of Critical Care Medicine, National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China
Hansi Lu, Outpatient Department, Department of Critical Care Medicine, National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China
James Oswald, School of Nanotechnology Engineering, University of Waterloo, Waterloo, ON N2L 3G1, Canada
Yongmei Liu, Outpatient Department, Department of Critical Care Medicine, National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China
Jun Zeng, Outpatient Department, Department of Critical Care Medicine, National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China
Chaohui Jin, Outpatient Department, Department of Critical Care Medicine, National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China
Xingchen Peng, Outpatient Department, Department of Critical Care Medicine, National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China
Jiyan Liu, Outpatient Department, Department of Critical Care Medicine, National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China
Xiangrong Song, Outpatient Department, Department of Critical Care Medicine, National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China

Keywords

ocular drug delivery, iRGD decorated liposomes, active corneal permeability, topical drops

Abstract

Ocular drug delivery remains a significant challenge that is limited by poor corneal retention and permeation, resulting in low ocular bioavailability (< 5%). Worse still, the most convenient and safe route of ocular drug administration, topical administration results in a drug bioavailability of less than 1%. iRGD modified drug delivery strategies have been developed for cancer therapy, however active targeting iRGD platforms for ocular drug delivery have yet to be explored. Herein, an iRGD modified liposomes was developed for ocular drug delivery via topical administration. The results indicated that iRGD modified liposomes could prolong the corneal retention time and enhance corneal permeability in an iRGD receptor mediated manner. These findings provided a novel strategy for topical ocular drug delivery for the treatment of posterior ocular diseases.

Graphical Abstract

Publisher

Tsinghua University Press

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