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Nano Research

Article Title

Real-time Raman detection by the cavity mode enhanced Raman scattering

Authors

Yang Liu, School of Physics and Technology, Wuhan University, Wuhan 430072, China Center for Nanoscience and Nanotechnology, Wuhan University, Wuhan 430072, China Key Laboratory of Artificial Micro- and Nano-structures of Ministry of Education, Wuhan University, Wuhan 430072, China
Xiaorui Tian, College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, China
Weiran Guo, School of Physics and Technology, Wuhan University, Wuhan 430072, China Center for Nanoscience and Nanotechnology, Wuhan University, Wuhan 430072, China Key Laboratory of Artificial Micro- and Nano-structures of Ministry of Education, Wuhan University, Wuhan 430072, China
Wenqiang Wang, School of Physics and Technology, Wuhan University, Wuhan 430072, China Center for Nanoscience and Nanotechnology, Wuhan University, Wuhan 430072, China Key Laboratory of Artificial Micro- and Nano-structures of Ministry of Education, Wuhan University, Wuhan 430072, China
Zhiqiang Guan, School of Physics and Technology, Wuhan University, Wuhan 430072, China Center for Nanoscience and Nanotechnology, Wuhan University, Wuhan 430072, China Key Laboratory of Artificial Micro- and Nano-structures of Ministry of Education, Wuhan University, Wuhan 430072, China
Hongxing Xu, School of Physics and Technology, Wuhan University, Wuhan 430072, China Center for Nanoscience and Nanotechnology, Wuhan University, Wuhan 430072, China Key Laboratory of Artificial Micro- and Nano-structures of Ministry of Education, Wuhan University, Wuhan 430072, China The Institute for Advanced Studies, Wuhan University, Wuhan 430072, China

Keywords

surface enhanced Raman scattering, cavity modes, microfluidics, bi-analyte, real-time detection

Abstract

Integrating surface enhanced Raman scattering with microfluidics is the long-term goal for reduced volume, multiplex and automation fingerprint detection of biomolecules. High sensitivity, repeatability, stability, reusability and real-time detection are the performance goals of Raman detection in the aqueous solution environment. Here, we reported the study on cavity mode enhanced SERS detection of both surface-adsorbed molecules and non-surface-adsorbed molecules in the solution environment. The cavity modes had important influence on the SERS enhancement, especially for the non-surface adsorbed molecules. Uniform, repeatable, reusable and real-time Raman signal detection of the non-surface adsorbed Rhodamine 6G molecules was demonstrated. Our work is an important step for the practical on-chip microfluidic Raman detection applications.

Graphical Abstract

Publisher

Tsinghua University Press

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