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Nano Research

Article Title

Shape-controlled synthesis of liquid metal nanodroplets for photothermal therapy

Authors

Junjie Yan, Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA Molecular Imaging Center, Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China Department of Bioengineering, University of California, Los Angeles, CA 90095, USA California NanoSystems Institute, University of California, Los Angeles, CA 90095, USA
Xudong Zhang, Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA Department of Bioengineering, University of California, Los Angeles, CA 90095, USA California NanoSystems Institute, University of California, Los Angeles, CA 90095, USA
Yang Liu, Department of Materials Science & Engineering, North Carolina State University, Raleigh, NC 27695, USA
Yanqi Ye, Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA Department of Bioengineering, University of California, Los Angeles, CA 90095, USA California NanoSystems Institute, University of California, Los Angeles, CA 90095, USA
Jicheng Yu, Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA Department of Bioengineering, University of California, Los Angeles, CA 90095, USA California NanoSystems Institute, University of California, Los Angeles, CA 90095, USA
Qian Chen, Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA Department of Bioengineering, University of California, Los Angeles, CA 90095, USA California NanoSystems Institute, University of California, Los Angeles, CA 90095, USA
Jinqiang Wang, Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA Department of Bioengineering, University of California, Los Angeles, CA 90095, USA California NanoSystems Institute, University of California, Los Angeles, CA 90095, USA
Yuqi Zhang, Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA Department of Bioengineering, University of California, Los Angeles, CA 90095, USA California NanoSystems Institute, University of California, Los Angeles, CA 90095, USA
Quanyin Hu, Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA Department of Bioengineering, University of California, Los Angeles, CA 90095, USA California NanoSystems Institute, University of California, Los Angeles, CA 90095, USA
Yang Kang, Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA Department of Bioengineering, University of California, Los Angeles, CA 90095, USA California NanoSystems Institute, University of California, Los Angeles, CA 90095, USA
Min Yang, Molecular Imaging Center, Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China
Zhen Gu, Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA Department of Bioengineering, University of California, Los Angeles, CA 90095, USA California NanoSystems Institute, University of California, Los Angeles, CA 90095, USA Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095, USA Center for Minimally Invasive Therapeutics, University of California, Los Angeles, CA 90095, USA

Keywords

liquid metal, melanin nanoparticles, nanomedicine, shape-controlled synthesis, photothermal therapy

Abstract

The capping agents for liquid metal (LM) nanodroplets in aqueous solutions are restricted to thiol-containing and positively-charged molecules or macromolecules. However, both thiolate-metal complex and electrostatic interaction are liable to detachment upon strong mechanical forces such as sonication, leading to limited stability and applications. To address this, we utilized ultrasmall water soluble melanin nanoparticles (MNPs) as the capping agent, which exhibited strong metal binding capability with the oxide layer of gallium based LMs and resulted in enhanced stability. Interestingly, shape-controlled synthesis of LM nanodroplets can be achieved by the incorporation of MNPs. Various EGaIn nanostructures including nanorice, nanosphere and nanorod were obtained by simply tuning the feed ratio, sonication time, and suspension temperature. Among these shapes, EGaIn nanorice has the best photothermal conversion efficiency, which could be leveraged for photothermal therapy.

Graphical Abstract

Publisher

Tsinghua University Press

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