•  
  •  
 
Nano Research

Article Title

Efficient renal clearance of DNA tetrahedron nanoparticles enables quantitative evaluation of kidney function

Authors

Dawei Jiang, Departments of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, 53705, USA Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Carson International Cancer Center, Laboratory of Evolutionary Theranostics, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen 518060, China
Hyung-Jun Im, Departments of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, 53705, USA Graduate School of Convergence Science and Technology, Seoul National University, Seoul 08826, Republic of Korea
Madeline E. Boleyn, Departments of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, 53705, USA Departments of Mathematics, and Biology, University of Wisconsin-Madison, Wisconsin 53705, USA
Christopher G. England, Departments of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, 53705, USA
Dalong Ni, Departments of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, 53705, USA
Lei Kang, Departments of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, 53705, USA Department of Nuclear Medicine, Peking University First Hospital, Beijing 100034, China
Jonathan W. Engle, Departments of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, 53705, USA
Peng Huang, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Carson International Cancer Center, Laboratory of Evolutionary Theranostics, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen 518060, China
Xiaoli Lan, Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology; Hubei Key Laboratory of Molecular Imaging, No. 1277 Jiefang Ave, Wuhan 430022, China
Weibo Cai, Departments of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, 53705, USA

Keywords

positron emission tomography (PET) imaging, DNA nanotechnology, DNA tetrahedron nanoparticle, renal clearance, kidney dysfunction

Abstract

DNA tetrahedron nanostructure (DTN) is one of the simplest DNA nanostructures and has been successfully applied for biosensing, imaging, and treatment of cancer. To facilitate its biomedical applications and potential clinical translation, fundamental understanding of DTN’s transportation among major organs in living organisms becomes increasingly important. Here, we describe the efficient renal clearance of DTN in healthy mice by using positron emission tomography (PET) imaging. The kidney elimination of DTN was later applied for renal function evaluation in murine models of unilateral ureteral obstruction (UUO). We further established a mathematical program of DTN to validate its changes of transportation pattern in healthy and UUO mice. We believe the establishment of pharmacokinetic profiles and mathematical model of DTN may provide insight for future optimization of DNA nanostructures for biomedical applications.

Graphical Abstract

Publisher

Tsinghua University Press

Share

COinS