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Nano Research

Article Title

All in one theranostic nanoplatform enables efficient anti-tumor peptide delivery for triple-modal imaging guided cancer therapy

Authors

Xiaoyan Qu, Frontier Institute of Science and Technology, Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, State Key Laboratory for Manufacturing Systems Engineering, Instrument Analysis Center, Xi’an Jiaotong University, Xi’an 710000, China
Zhengqing Liu, School of Materials Science and Engineering, National Institute for Advanced Materials, Center for Rare Earth and Inorganic Functional Materials, Nankai University, Tianjin 300350, China
Bohan Ma, Frontier Institute of Science and Technology, Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, State Key Laboratory for Manufacturing Systems Engineering, Instrument Analysis Center, Xi’an Jiaotong University, Xi’an 710000, China
Na Li, Frontier Institute of Science and Technology, Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, State Key Laboratory for Manufacturing Systems Engineering, Instrument Analysis Center, Xi’an Jiaotong University, Xi’an 710000, China Center for Functional Nanomaterials, Brookhaven National Laboratory, Upton, New York 11973, USA
Hongyang Zhao, Frontier Institute of Science and Technology, Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, State Key Laboratory for Manufacturing Systems Engineering, Instrument Analysis Center, Xi’an Jiaotong University, Xi’an 710000, China
Tian Yang, Department of Radiation Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710000, China
Yumeng Xue, Frontier Institute of Science and Technology, Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, State Key Laboratory for Manufacturing Systems Engineering, Instrument Analysis Center, Xi’an Jiaotong University, Xi’an 710000, China
Xiaozhi Zhang, Department of Radiation Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710000, China
Yongping Shao, Frontier Institute of Science and Technology, Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, State Key Laboratory for Manufacturing Systems Engineering, Instrument Analysis Center, Xi’an Jiaotong University, Xi’an 710000, China
Ying Chang, Frontier Institute of Science and Technology, Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, State Key Laboratory for Manufacturing Systems Engineering, Instrument Analysis Center, Xi’an Jiaotong University, Xi’an 710000, China
Jun Xu, School of Materials Science and Engineering, National Institute for Advanced Materials, Center for Rare Earth and Inorganic Functional Materials, Nankai University, Tianjin 300350, China
Bo Lei, Frontier Institute of Science and Technology, Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, State Key Laboratory for Manufacturing Systems Engineering, Instrument Analysis Center, Xi’an Jiaotong University, Xi’an 710000, China
Yaping Du, School of Materials Science and Engineering, National Institute for Advanced Materials, Center for Rare Earth and Inorganic Functional Materials, Nankai University, Tianjin 300350, China

Keywords

rare earth nanoparticles, multifunctional property, peptide delivery, tumor imaging, tumor therapy

Abstract

Developing a reliable system to efficiently and safely deliver peptide drugs into tumor tissues still remains a great challenge since the instability of peptide drugs and low ability to traverse the cell membrane. Herein, we constructed a multifunctional nanoplatform based on porous europium/gadolinium (Eu/Gd)-doped NaLa(MoO4)2 nanoparticles (NLM NPs) to deliver antitumor peptide of B-cell lymphoma/leukemia-2-like protein 11 (BIM) for cancer therapy. The porous NLM NPs exhibited inherent photoluminescent, magnetic and X-ray absorbable properties, which enable them for triple-modal bioimaging, including fluorescence, magnetic resonance imaging (MRI) and computed tomography (CT). This triple-modal bioimaging can contribute to monitoring NLM NPs biodistribution and guiding therapy in vitro and in vivo. Furthermore, the NLM NPs showed negligible cytotoxicity in vitro and tissue toxicity in vivo. Importantly, NLM NPs could load the antitumor peptide of BIM and efficiently improve the resistance of peptide drugs to proteolysis. The BIM peptide was efficiently delivered into the tumor cells by NLM NPs, which can inhibit the growth and promote the apoptosis of cancer cells in vitro, significantly inhibit the tumor growth in vivo. Notably, NLM-BIM theranostic nanoplatform exhibits low systemic toxicity and fewer side effects in vivo. The NLM NPs can serve as a promising multifunctional peptide delivery nanoplatform for multi-modal bioimaging and cancer therapy.

Graphical Abstract

Publisher

Tsinghua University Press

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