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Nano Research

Article Title

Radioiodinated tyrosine based carbon dots with efficient renal clearance for single photon emission computed tomography of tumor

Authors

Nian Liu, State Key Laboratory of Natural Medicines, Key Laboratory of Drug Quality Control and Pharmacovigilance, Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China Institute of Biological and Medical Imaging, Helmholtz Zentrum München and Technische Universitt München, Neuherberg 85764, Germany State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361005, China
Yiyue Shi, State Key Laboratory of Natural Medicines, Key Laboratory of Drug Quality Control and Pharmacovigilance, Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China
Jingru Guo, State Key Laboratory of Natural Medicines, Key Laboratory of Drug Quality Control and Pharmacovigilance, Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China
Hai Li, Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou 215123, China
Qiang Wang, Department of Nuclear Medicine, Zhongshan Hospital Xiamen University, Xiamen 361004, China
Menglin Song, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361005, China
Zhiyuan Shi, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361005, China
Le He, Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou 215123, China
Xinhui Su, Department of Nuclear Medicine, Zhongshan Hospital Xiamen University, Xiamen 361004, China
Jin Xie, Department of Chemistry, Bio-Imaging Research Center, University of Georgia, Athens, Georgia 30602, USA
Xiaolian Sun, State Key Laboratory of Natural Medicines, Key Laboratory of Drug Quality Control and Pharmacovigilance, Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China

Keywords

radioiodination, tyrosine based carbon dots, single photon emission computed tomography (SPECT) imaging, fluoresecent imaging, renal clearance

Abstract

Nanoparticles with effective tumor accumulation and efficient renal clearance have attracted significant interests for clinical applications. We prepared 2.5 nm tyrosine based carbon dots (TCDs) with phenolic hydroxyl groups on the surface for directly 125I labeling. The 125I labeled polyethylene glycol (PEG) functionalized TCDs (125I-TCDPEGs) showed excellent radiochemical stability both in vitro and in vivo. Due to the enhanced permeability and retention effect, these 125I-TCDPEGs demonstrated a tumor accumulation around 4%–5% of the injected dose per gram (ID/g) for U87MG, 4T1, HepG2 and MCF7 tumor-bearing mice at 1 h post-injection. Meanwhile, the 125I-TCDPEGs also could be fast renally excreted, with less than 0.6% ID/g left in the liver and spleen within 24 h. These radioactive carbon dots not only can be used for cellular fluorescence imaging due to their intrinsic optical property, but are also effective single photon emission computed tomography (SPECT) imaging agents for tumor. Together with their excellent biocompatibility and stability, we anticipate these 125I-TCDPEGs of great potential for early tumor diagnosis in clinic. What’s more, our TCDPEGs are also proved to be feasible carriers for other iodine isotopes such as 127I and 131I for different biomedical application.

Graphical Abstract

Publisher

Tsinghua University Press

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