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Nano Research

Article Title

Special interstitial route can transport nanoparticles to the brain bypassing the blood-brain barrier

Authors

Nan Hu, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China School of Future Technology, University of Chinese Academy of Sciences, Beijing 100049, China Department of Traditional Chinese Medicine, Chengde Medical University, Chengde 066000, China
Xiaoli Shi, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China School of Future Technology, University of Chinese Academy of Sciences, Beijing 100049, China
Qiang Zhang, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China School of Future Technology, University of Chinese Academy of Sciences, Beijing 100049, China
Wentao Liu, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China School of Future Technology, University of Chinese Academy of Sciences, Beijing 100049, China
Yuting Zhu, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China School of Future Technology, University of Chinese Academy of Sciences, Beijing 100049, China
Yuqing Wang, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China School of Future Technology, University of Chinese Academy of Sciences, Beijing 100049, China
Yi Hou, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
Yinglu Ji, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China
Yupeng Cao, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China School of Future Technology, University of Chinese Academy of Sciences, Beijing 100049, China
Qian Zeng, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China School of Future Technology, University of Chinese Academy of Sciences, Beijing 100049, China
Zhuo Ao, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China School of Future Technology, University of Chinese Academy of Sciences, Beijing 100049, China
Quanmei Sun, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China School of Future Technology, University of Chinese Academy of Sciences, Beijing 100049, China
Xiaohan Zhou, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China School of Future Technology, University of Chinese Academy of Sciences, Beijing 100049, China
Xiaochun Wu, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China
Dong Han, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China School of Future Technology, University of Chinese Academy of Sciences, Beijing 100049, China

Keywords

nanoparticles, interstitial stream, mass transportation, blood-brain barrier, magnetic resonance imaging

Abstract

Nowadays, nanoparticles (NPs) are considered to be ideal tools for bioimaging and drug delivery. Although increasing research has focused on NP biodistribution, transportation in the interstitial architecture has been neglected. The entire body is connected by the interstitial architecture, which can provide a long-range and direct pathway for NP biodistribution in a nonvascular system. In this study, we report that 10-nm gold NPs injected directly into the interstitial architecture of the tarsal tunnel of rats (intervaginal space injection (ISI)) were delivered to the brain without crossing the blood-brain barrier. Furthermore, NaGdF4 nanoparticles were used to explore the transportation route by magnetic resonance imaging. The results demonstrated that, after ISI, the NaGdF4 nanoparticles were transported through the perivascular interstitial space of the carotid arteries and brain vessels to the brain. This is a special nonvascular transportation route like a stream based on the interstitial architecture that provides an alternative pathway for NP biodistribution.

Graphical Abstract

Publisher

Tsinghua University Press

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