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Nano Research

Article Title

Customized lipid-coated magnetic mesoporous silica nanoparticle doped with ceria nanoparticles for theragnosis of intracerebral hemorrhage

Authors

Bong Geun Cha, School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea
Han-Gil Jeong, Department of Laboratory of Innovative Nanobiotechnology, Biomedical Research Institute, Seoul National University Hospital 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea Department of Neurology, Seoul National University Hospital 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea
Dong-Wan Kang, Department of Laboratory of Innovative Nanobiotechnology, Biomedical Research Institute, Seoul National University Hospital 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea Department of Neurology, Seoul National University Hospital 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea
Myong-Joo Nam, School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea
Chi Kyung Kim, Department of Laboratory of Innovative Nanobiotechnology, Biomedical Research Institute, Seoul National University Hospital 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea Department of Neurology, Korea University Guro Hospital and Korea University College of Medicine, Seoul 08308, Republic of Korea
Do Yeon Kim, Department of Laboratory of Innovative Nanobiotechnology, Biomedical Research Institute, Seoul National University Hospital 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea Department of Neurology, Seoul National University Hospital 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea
In-Young Choi, Department of Laboratory of Innovative Nanobiotechnology, Biomedical Research Institute, Seoul National University Hospital 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea Department of Neurology, Seoul National University Hospital 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea
Seul Ki Ki, Department of Laboratory of Innovative Nanobiotechnology, Biomedical Research Institute, Seoul National University Hospital 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea Department of Neurology, Seoul National University Hospital 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea
Song I. Kim, Department of Laboratory of Innovative Nanobiotechnology, Biomedical Research Institute, Seoul National University Hospital 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea Department of Neurology, Seoul National University Hospital 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea
Ju hee Han, Department of Laboratory of Innovative Nanobiotechnology, Biomedical Research Institute, Seoul National University Hospital 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea Department of Neurology, Seoul National University Hospital 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea
Jaeyun Kim, School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea Department of Health Sciences and Technology, Samsung Advanced Institute for Health Science & Technology (SAIHST), Sungkyunkwan University, Suwon 16419, Republic of Korea Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea
Seung-Hoon Lee, Department of Laboratory of Innovative Nanobiotechnology, Biomedical Research Institute, Seoul National University Hospital 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea Department of Neurology, Seoul National University Hospital 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea

Keywords

magnetic mesoporous silica nanoparticle, ceria nanoparticles, intracerebral hemorrhage, reactive oxygen species, therapeutics, imaging

Abstract

ABSTRACT Intracerebral hemorrhage (ICH), caused by the sudden rupture of an artery within the brain, is a devastating subtype of stroke, which currently has no effective treatment. Intense inflammatory reactions that occur in the peri-hematomal area after ICH are more deleterious than the hematoma itself, resulting in subsequent brain edema and neurologic deterioration. Thus, we developed lipid-coated magnetic mesoporous silica nanoparticles doped with ceria nanoparticles (CeNPs), abbreviated as LMCs, which have both potent anti-inflammatory therapeutic effects via scavenging reactive oxygen species and help in increasing the efficacy of magnetic resonance imaging enhancement in the peri-hematomal area. LMCs consist of mesoporous silica nanoparticle-supported lipid bilayers, which are loaded with large amounts of CeNPs for scavenging of reactive oxygen species, and iron oxide nanoparticles for magnetic resonance imaging contrast. LMCs loaded with CeNPs exhibited strong anti-oxidative and anti-inflammatory activities in vitro. In the rodent ICH model, intracerebrally injected LMCs reached the peri-hematomal area and were engulfed by macrophages, which were clearly visualized by magnetic resonance imaging of the brain. Moreover, LMCs reduced inflammatory macrophage infiltration, and thus significantly reduced brain edema. Finally, LMC treatment markedly improved neurologic outcomes of the animals with ICH. Thus, LMC is the first nanobiomaterial that successfully showed theragnostic effects in ICH.

Graphical Abstract

Publisher

Tsinghua University Press

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