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Nano Research

Article Title

Calcium carbonate-doxorubicin@silica-indocyanine green nanospheres with photo-triggered drug delivery enhance cell killing in drug-resistant breast cancer cells

Authors

Wei Wang, Division of Nanomaterials & Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, Collaborative Innovation Center of Suzhou Nano Science and Technology, Department of Chemistry, CAS Centre for Excellence in Nanoscience, Hefei Science Centre of CAS, University of Science and Technology of China, Hefei 230026, China
Yang Zhao, Division of Nanomaterials & Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, Collaborative Innovation Center of Suzhou Nano Science and Technology, Department of Chemistry, CAS Centre for Excellence in Nanoscience, Hefei Science Centre of CAS, University of Science and Technology of China, Hefei 230026, China
Bei-Bei Yan, Division of Nanomaterials & Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, Collaborative Innovation Center of Suzhou Nano Science and Technology, Department of Chemistry, CAS Centre for Excellence in Nanoscience, Hefei Science Centre of CAS, University of Science and Technology of China, Hefei 230026, China
Liang Dong, Division of Nanomaterials & Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, Collaborative Innovation Center of Suzhou Nano Science and Technology, Department of Chemistry, CAS Centre for Excellence in Nanoscience, Hefei Science Centre of CAS, University of Science and Technology of China, Hefei 230026, China
Yang Lu, School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei 230009, China
Shu-Hong Yu, Division of Nanomaterials & Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, Collaborative Innovation Center of Suzhou Nano Science and Technology, Department of Chemistry, CAS Centre for Excellence in Nanoscience, Hefei Science Centre of CAS, University of Science and Technology of China, Hefei 230026, China

Keywords

calcium carbonate-based structures, photothermal therapy, photodynamic therapy, combined therapeutic effects

Abstract

ABSTRACT Calcium carbonate-doxorubicin@silica-indocyanine green nanospheres with high uniformity and monodispersity were designed and synthesized, in order to provide a photo-triggered strategy for drug-resistant cancer therapy. Under near-infrared laser irradiation, the nanospheres transformed laser power into local heat and reactive oxygen species via the connected indocyanine green molecule, thus exhibiting photothermal and photodynamic effects. Moreover, the photo-triggered drug release based on calcium-assisted silica degradation was observed, endowing the nanospheres with chemotherapeutic properties. Finally, combined therapeutic effects against drug-resistant human breast cancer cells were successfully obtained. These photo-triggered materials based on calcium carbonate could provide a promising platform for enhanced multimodal cancer therapies.

Graphical Abstract

Publisher

Tsinghua University Press

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