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Nano Research

Article Title

Doxorubicin-loaded Fe3O4@MoS2-PEG-2DG nanocubes as a theranostic platform for magnetic resonance imaging-guided chemo-photothermal therapy of breast cancer

Authors

Wensheng Xie, State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science & Engineering, Tsinghua University, Beijing 100084, China Key Laboratory of Advanced Materials, Ministry of Education of China, School of Materials Science & Engineering, Tsinghua University, Beijing 100084, China
Qin Gao, State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science & Engineering, Tsinghua University, Beijing 100084, China Key Laboratory of Advanced Materials, Ministry of Education of China, School of Materials Science & Engineering, Tsinghua University, Beijing 100084, China
Dan Wang, State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science & Engineering, Tsinghua University, Beijing 100084, China Key Laboratory of Advanced Materials, Ministry of Education of China, School of Materials Science & Engineering, Tsinghua University, Beijing 100084, China
Zhenhu Guo, State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science & Engineering, Tsinghua University, Beijing 100084, China Key Laboratory of Advanced Materials, Ministry of Education of China, School of Materials Science & Engineering, Tsinghua University, Beijing 100084, China
Fei Gao, School of Chemical and Biomolecular Engineering, National University of Singapore, 119077, Singapore
Xiumei Wang, State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science & Engineering, Tsinghua University, Beijing 100084, China Key Laboratory of Advanced Materials, Ministry of Education of China, School of Materials Science & Engineering, Tsinghua University, Beijing 100084, China
Qiang Cai, State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science & Engineering, Tsinghua University, Beijing 100084, China Key Laboratory of Advanced Materials, Ministry of Education of China, School of Materials Science & Engineering, Tsinghua University, Beijing 100084, China
Si-shen Feng, School of Chemical and Biomolecular Engineering, National University of Singapore, 119077, Singapore
Haiming Fan, College of Chemistry and Materials Science, Northwest University, Xi’an 710069, China
Xiaodan Sun, State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science & Engineering, Tsinghua University, Beijing 100084, China Key Laboratory of Advanced Materials, Ministry of Education of China, School of Materials Science & Engineering, Tsinghua University, Beijing 100084, China
Lingyun Zhao, State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science & Engineering, Tsinghua University, Beijing 100084, China Key Laboratory of Advanced Materials, Ministry of Education of China, School of Materials Science & Engineering, Tsinghua University, Beijing 100084, China

Keywords

iron oxide nanocubes, molybdenum disulfide, multimodality therapy, photothermal therapy, nanotheranostics

Abstract

ABSTRACT Molybdenum disulfide (MoS2), a typical transition-metal dichalcogenide, has attracted increasing attention in the field of nanomedicine because of its preeminent properties. In this study, magnetic resonance imaging (MRI)-guided chemo-photothermal therapy of human breast cancer xenograft in nude mice was demonstrated using a novel core/shell structure of Fe3O4@MoS2 nanocubes (IOMS NCs) via the integration of MoS2 (MS) film onto iron oxide (IO) nanocubes through a facile hydrothermal method. After the necessary PEGylation modification of the NCs for long-circulation purposes, such PEGylated NCs were further capped by 2-deoxy-D-glucose (2-DG), a non-metabolizable glucose analogue to increase the accumulation of the as-prepared NCs at the tumor site, as 2-DG molecules could be particularly attractive to resource-hungry cancer cells. Such 2-DGmodified PEGylated NCs (IOMS-PEG-2DG NCs) acted as drug-carriers for doxorubicin (DOX), which could be easily loaded within the NCs. The obtained IOMS-PEG(DOX)-2DG NCs exhibited a T2 relaxivity coefficient of 48.86 (mM)−1·s−1 and excellent photothermal performance. 24 h after intravenous injection of IOMS-PEG(DOX)-2DG NCs, the tumor site was clearly detected by enhanced T2-weighted MRI signal. Upon exposure to an NIR 808-nm laser for 5 min at a low power density of 0.5 W·cm−2, a marked temperature increase was noticed within the tumor site, and the tumor growth was efficiently inhibited by the chemo-photothermal effect. Therefore, our study highlights an excellent theranostic platform with great potential for targeted MRI-guided precise chemo-photothermal therapy of breast cancer.

Graphical Abstract

Publisher

Tsinghua University Press

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