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Nano Research

Article Title

Ultrasensitive detection of Ebola matrix protein in a memristor mode

Authors

Bergoi Ibarlucea, Institute of Materials Science, Max Bergmann Center for Biomaterials, Technische Universitt Dresden, Budapester Str. 27, Dresden 01069, Germany Center for Advancing Electronics Dresden (CFAED), Technische Universitt Dresden, Dresden 01069, Germany
Teuku Fawzul Akbar, Institute of Materials Science, Max Bergmann Center for Biomaterials, Technische Universitt Dresden, Budapester Str. 27, Dresden 01069, Germany
Kihyun Kim, Department of Creative IT Engineering, Pohang University of Science and Technology, Pohang 37673, Republic of Korea
Taiuk Rim, Department of Creative IT Engineering, Pohang University of Science and Technology, Pohang 37673, Republic of Korea
Chang-Ki Baek, Department of Creative IT Engineering, Pohang University of Science and Technology, Pohang 37673, Republic of Korea
Alon Ascoli, Chair of Fundamentals of Electrical Engineering, Technische Universitt Dresden, Mommsenstrae 12, Dresden 01069, Germany
Ronald Tetzlaff, Chair of Fundamentals of Electrical Engineering, Technische Universitt Dresden, Mommsenstrae 12, Dresden 01069, Germany
Larysa Baraban, Institute of Materials Science, Max Bergmann Center for Biomaterials, Technische Universitt Dresden, Budapester Str. 27, Dresden 01069, Germany Center for Advancing Electronics Dresden (CFAED), Technische Universitt Dresden, Dresden 01069, Germany
Gianaurelio Cuniberti, Institute of Materials Science, Max Bergmann Center for Biomaterials, Technische Universitt Dresden, Budapester Str. 27, Dresden 01069, Germany Center for Advancing Electronics Dresden (CFAED), Technische Universitt Dresden, Dresden 01069, Germany

Keywords

memristor biosensor, capacitance, honeycomb nanowires, silicon nanowire field effect transistor, VP40 matrix protein, Ebola detection

Abstract

ABSTRACT We demonstrate the direct biosensing of the Ebola VP40 matrix protein, using a memristor mode of a liquid-integrated nanodevice, based on a large array of honeycomb-shaped silicon nanowires. To shed more light on the principle of biodetection using memristors, we engineered the opening of the current-minima voltage gap VGAP by involving the third gap-control electrode (gate voltage, VG) into the system. The primary role of VG is to mimic the presence of the charged species of the desired sign at the active area of the sensor. We further showed the advantages of biodetection with an initially opened controlled gap (VGAP ≠ 0), which allows the detection of the lowest concentrations of the biomolecules carrying arbitrary positive or negative charges; this feature was not present in previous configurations. We compared the bio-memristor performance, in terms of its detection range and sensitivity, to that of the already-known field-effect transistor (FET) mode by operating the same device. To our knowledge, this is the first demonstration of Ebola matrix protein detection using a nanoscaled electrical sensor.

Graphical Abstract

Publisher

Tsinghua University Press

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