Article Title
A facile fabrication route for binary transition metal oxide-based Janus nanoparticles for cancer theranostic applications
Authors
M. Zubair Iqbal, Key Laboratory of Magnetic Materials and Devices, CAS & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, & Division of Functional Materials and Nano devices, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China
Wenzhi Ren, Key Laboratory of Magnetic Materials and Devices, CAS & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, & Division of Functional Materials and Nano devices, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China
Madiha Saeed, Key Laboratory of Magnetic Materials and Devices, CAS & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, & Division of Functional Materials and Nano devices, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China
Tianxiang Chen, Key Laboratory of Magnetic Materials and Devices, CAS & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, & Division of Functional Materials and Nano devices, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China
Xuehua Ma, Key Laboratory of Magnetic Materials and Devices, CAS & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, & Division of Functional Materials and Nano devices, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China
Xu Yu, Key Laboratory of Magnetic Materials and Devices, CAS & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, & Division of Functional Materials and Nano devices, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China
Jichao Zhang, Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201204, China
Lili Zhang, Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201204, China
Aiguo Li, Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201204, China
Aiguo Wu, Key Laboratory of Magnetic Materials and Devices, CAS & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, & Division of Functional Materials and Nano devices, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China
Keywords
Janus nanostructures, manganese oxide, magnetic resonance imaging, photodynamic therapy, breast cancer
Abstract
ABSTRACT Janus nanoparticles (JNPs) have multiple configurations for molecular imaging, targeting, and therapeutic effects on cancers; these properties have made these particles attractive for biomedical applications. Nonetheless, smart strategies for the controlled synthesis in a liquid phase and exploration of the appropriate applications of JNPs remain a challenge. In this study, a unique liquid-phase method was applied to fabricate Mn3O4-TiO2/ZnO/Fe3O4 multifunctional binary transition metal oxide-based JNPs, using the concept of epitaxial growth and lattice mismatch among synthesized materials. Transmission electron microscopy and scanning transmission electron microscopy results revealed that the created materials are embedded in the form of dimers with good dispersion and homogeneous growth in a nonpolar solvent. Pluronic® F-127-coated Mn3O4- TiO2 JNPs were utilized as a contrast agent in T1-weighted magnetic resonance imaging (MRI) and in photodynamic therapy (PDT) for cancers in vitro and in vivo. In vivo T1-weighted MRI of the heart, liver, and kidneys in mice after intravenous injection of the nanoparticles revealed high sensitivity and biocompatibility of as-synthesized Mn3O4-TiO2 JNPs. Results of synchrotron X-ray fluorescence microscopy mapping showed the stability of the nanocomposites and efficiency of penetration into the cytoplasm and perinuclear area. Inorganic TiO2 photosensitizers showed promising tumor ablation performance in PDT in vitro and in vivo at low intensity of UV irradiation (5.6 mWcm–2) because of their ultrasmall size and photodegradable stability. These results reveal that multifunctional Mn3O4-TiO2 JNPs enhance a T1-weighted MRI contrast and have excellent properties for PDT and therefore, may be a novel agent for cancer theranostics.
Graphical Abstract
Publisher
Tsinghua University Press
Recommended Citation
M. Zubair Iqbal,Wenzhi Ren,Madiha Saeed,Tianxiang Chen,Xuehua Ma,Xu Yu,Jichao Zhang,Lili Zhang,Aiguo Li,Aiguo Wu, A facile fabrication route for binary transition metal oxide-based Janus nanoparticles for cancer theranostic applications. NanoRes.2018, 11(10): 5735–5750
