Selenium-functionalized metal-organic frameworks as enzyme mimics
metal-organic frameworks, nano chemistry, selenium chemistry, enzyme mimic, postsynthetic modification
ABSTRACT The development of artificial enzyme mimics has been rapidly growing in recent years, and it is attracting increasing attention owing to their remarkable advantages over natural enzymes. Herein, we developed a general and facile method to fabricate efficient glutathione peroxidase (GPx) mimics by grafting selenium-containing molecules (phenylselenylbromide, PhSeBr) to a Zr(IV)-based UiO-66-NH2 framework. In the presence of glutathione (GSH) serving as substrate, the fabricated UiO-66-Se catalysts can catalyze the reduction of hydroperoxides. The as-prepared UiO-66-Se systems show good catalytic activity over three cycles. These high-efficiency GPx mimic metal-organic frameworks (MOFs) are endowed with excellent thermal and structural stability, providing a promising avenue for the development of artificial enzyme mimics.
Tsinghua University Press
Weiqiang Zhou,Hongfeng Li,Bin Xia,Wenlan Ji,Shaobo Ji,Weina Zhang,Wei Huang,Fengwei Huo,Huaping Xu, Selenium-functionalized metal-organic frameworks as enzyme mimics. NanoRes.2018, 11(10): 5761–5768