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Nano Research

Article Title

A series of nanoparticles with phase-separated structures by 1,1-diphenylethene controlled one-step soap-free emulsion copolymerization and their application in drug release

Authors

Xinlong Fan, Department of Applied Chemistry, School of Natural and Applied Sciences, Northwestern Polytechnical University, No. 127, West Youyi Road, Xi’an 710072, China
Jin Liu, Department of Applied Chemistry, School of Natural and Applied Sciences, Northwestern Polytechnical University, No. 127, West Youyi Road, Xi’an 710072, China
Xiangkun Jia, Department of Applied Chemistry, School of Natural and Applied Sciences, Northwestern Polytechnical University, No. 127, West Youyi Road, Xi’an 710072, China
Yin Liu, Department of Applied Chemistry, School of Natural and Applied Sciences, Northwestern Polytechnical University, No. 127, West Youyi Road, Xi’an 710072, China
Hao Zhang, Department of Applied Chemistry, School of Natural and Applied Sciences, Northwestern Polytechnical University, No. 127, West Youyi Road, Xi’an 710072, China
Shenqiang Wang, Department of Applied Chemistry, School of Natural and Applied Sciences, Northwestern Polytechnical University, No. 127, West Youyi Road, Xi’an 710072, China
Baoliang Zhang, Department of Applied Chemistry, School of Natural and Applied Sciences, Northwestern Polytechnical University, No. 127, West Youyi Road, Xi’an 710072, China
Hepeng Zhang, Department of Applied Chemistry, School of Natural and Applied Sciences, Northwestern Polytechnical University, No. 127, West Youyi Road, Xi’an 710072, China
Qiuyu Zhang, Department of Applied Chemistry, School of Natural and Applied Sciences, Northwestern Polytechnical University, No. 127, West Youyi Road, Xi’an 710072, China

Keywords

phase separation, 1, 1-diphenylethene controlled polymerization, porous, nanocapsules, controlled release

Abstract

ABSTRACT A facile one-step approach to synthesize various phase-separated porous, raspberry-like, flower-like, core–shell and anomalous nanoparticles and nanocapsules via 1,1-diphenylethene (DPE) controlled soap-free emulsion copolymerization of styrene (S) with glycidyl methacrylate (GMA), or acrylic acid (AA) is reported. By regulating the mass ratio of S/GMA, transparent polymer solution, porous and anomalous P(S-GMA) particles could be produced. The P(S-GMA) particles turn from flower-like to raspberry-like and then to anomalous structures with smooth surface as the increase of divinylbenzene (DVB) crosslinker. Transparent polymer solution, nanocapsules and core–shell P(S-AA) particles could be obtained by altering the mole ratio of S/AA; anomalous and raspberry-like P(S-AA) particles are produced by adding DVB. The unpolymerized S resulted from the low monomer conversion in the presence of DPE aggregates to form nano-sized droplets, and migrates towards the external surfaces of the GMA-enriched P(S-GMA) particles and the internal bulk of the AA-enriched P(S-AA) particles. The nano-sized droplets function as in situ porogen, porous P(S-GMA) particles and P(S-AA) nanocapsules are produced when the porogen is removed. This novel, facile, one-step method with excellent controllability and reproducibility will inspire new strategies for creating hierarchical phase-separated polymeric particles with various structures by simply altering the species and ratio of comonomers. The drug loading and release experiments on the porous particles and nanocapsules demonstrate that the release of doxorubicin hydrochloride is very slow in weakly basic environment and quick in weakly acidic environment, which enables the porous particles and nanocapsules with promising potential in drug delivery applications.

Graphical Abstract

Publisher

Tsinghua University Press

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