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Nano Research

Article Title

Folate targeted coated SPIONs as efficient tool for MRI

Authors

Cinzia Scialabba, Department of Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), University of Palermo, 90123 Palermo, Italy
Roberto Puleio, Istituto Zooprofilattico Sperimentale della Sicilia “A. Mirri”, Via Gino Marinuzzi 3, 90100 Palermo, Italy
Davide Peddis, Institute of Structure of Matter National Research Council (CNR), Via Salaria, 00015 Monterotondo Scalo (RM), Italy
Gaspare Varvaro, Institute of Structure of Matter National Research Council (CNR), Via Salaria, 00015 Monterotondo Scalo (RM), Italy
Pietro Calandra, Istituto per lo Studio dei Materiali Nanostrutturati Consiglio Nazionale delle Ricerche, Via Salaria km. 29.300, 00015 Monterotondo Stazione (RM), Italy
Giovanni Cassata, Istituto Zooprofilattico Sperimentale della Sicilia “A. Mirri”, Via Gino Marinuzzi 3, 90100 Palermo, Italy
Luca Cicero, Istituto Zooprofilattico Sperimentale della Sicilia “A. Mirri”, Via Gino Marinuzzi 3, 90100 Palermo, Italy
Mariano Licciardi, Department of Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), University of Palermo, 90123 Palermo, Italy Mediterranean Center for Human Health Advanced Biotechnologies (CHAB), ATeNCenter, University of Palermo, 90100 Palermo, Italy
Gaetano Giammona, Department of Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), University of Palermo, 90123 Palermo, Italy Mediterranean Center for Human Health Advanced Biotechnologies (CHAB), ATeNCenter, University of Palermo, 90100 Palermo, Italy

Keywords

inulin copolymer, superparamagnetic spinel iron oxide nanoparticles (SPIONs), magnetic resonance imaging (MRI), folic acid (FA), cancer targeting

Abstract

ABSTRACT The development of more sensitive diagnostic tools allowing an early-stage and highly efficient medical imaging of tumors remains a challenge. Magnetic nanoparticles seem to be the contrast agents with the highest potential, if properly constructed. Therefore, in this study, hybrid magnetic nanoarchitectures were developed using a new amphiphilic inulin-based graft copolymer (INU-LAPEG-FA) as coating material for 10-nm spinel iron oxide (magnetite, Fe3O4) superparamagnetic nanoparticles (SPION). Folic acid (FA) covalently linked to the coating copolymer in order to be exposed onto the nanoparticle surface was chosen as the targeting agent because folate receptors are upregulated in many cancer types. Physicochemical characterization and in vitro biocompatibility study was then performed on the prepared magnetic nanoparticles. The improved targeting and imaging properties of the prepared FA-SPIONs were further evaluated in nude mice using 7-Tesla magnetic resonance imaging (MRI). FA-SPIONs exhibited the ability to act as efficient contrast agents in conventional MRI, providing a potential nanoplatform not only for tumor diagnosis but also for cancer treatment, through the delivery of anticancer drug or locoregional magnetic hyperthermia.

Graphical Abstract

Publisher

Tsinghua University Press

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