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Nano Research

Article Title

Near-infrared (NIR) controlled reversible cell adhesion on a responsive nano-biointerface

Authors

Haijun Cui, CAS Key Laboratory of Bio-inspired Materials and Interfacial Science, CAS Center for Excellence in Nanoscience, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences (CAS), Beijing 100190, China University of Chinese Academy of Sciences (UCAS), Beijing 100049, China
Pengchao Zhang, University of Chinese Academy of Sciences (UCAS), Beijing 100049, China Beijing National Laboratory for Molecular Sciences (BNLMS), Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
Wenshuo Wang, CAS Key Laboratory of Bio-inspired Materials and Interfacial Science, CAS Center for Excellence in Nanoscience, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences (CAS), Beijing 100190, China University of Chinese Academy of Sciences (UCAS), Beijing 100049, China
Guannan Li, University of Chinese Academy of Sciences (UCAS), Beijing 100049, China Beijing National Laboratory for Molecular Sciences (BNLMS), Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
Yuwei Hao, University of Chinese Academy of Sciences (UCAS), Beijing 100049, China Beijing National Laboratory for Molecular Sciences (BNLMS), Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
Luying Wang, University of Chinese Academy of Sciences (UCAS), Beijing 100049, China Beijing National Laboratory for Molecular Sciences (BNLMS), Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
Shutao Wang, CAS Key Laboratory of Bio-inspired Materials and Interfacial Science, CAS Center for Excellence in Nanoscience, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences (CAS), Beijing 100190, China University of Chinese Academy of Sciences (UCAS), Beijing 100049, China

Keywords

cell adhesion, photothermal effect, nanostructures, bio-interface, hydrophobic interaction

Abstract

ABSTRACT Light-activated dynamic variations have promoted the development of smart interfaces, especially nano-biointerfaces. In this article, the near-infrared (NIR)- responsive surface for controlling cell adhesion was designed by grafting a thermal responsive polymer (poly(N-isopropylacrylamide), PNIPAM) onto silicon nanowires (SiNWs) instead of the traditional photosensitive moieties. NIR induced the photothermal effect of the SiNWs, and the local heat induced thermodynamic phase transformation of PNIPAM. With the application of NIR radiation, the surface turned to a hydrophobic state, and restored to the hydrophilic state when NIR was switched off, leading to reversible cell adhesion and release. The switchable wettability of the surface and cell adhesion/release occurred efficiently even after 20 cycles. Proteins were anchored on the surface via hydrophobic interactions using NIR; further connection of a cell-capture agent helped in achieving specific cell capture. This dynamic control of cell adhesion via NIR may provide new clues for designing functional nano-biointerfaces.

Graphical Abstract

Publisher

Tsinghua University Press

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