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Nano Research

Article Title

Ultrasound-triggered noninvasive regulation of blood glucose levels using microgels integrated with insulin nanocapsules

Authors

Jin Di, Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA Center for Nanotechnology in Drug Delivery and Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Jicheng Yu, Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA Center for Nanotechnology in Drug Delivery and Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Qun Wang, Department of Chemical and Biological Engineering, Iowa State University, Ames, IA 50011, USA
Shanshan Yao, Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695, USA
Dingjie Suo, Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695, USA
Yanqi Ye, Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA Center for Nanotechnology in Drug Delivery and Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Matthew Pless, Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695, USA
Yong Zhu, Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695, USA
Yun Jing, Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695, USA
Zhen Gu, Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA Center for Nanotechnology in Drug Delivery and Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA

Keywords

controlled drug delivery, focused ultrasound, diabetes, nanocapsule, microgel

Abstract

ABSTRACT Diabetes is a serious public health problem affecting 422 million people worldwide. Traditional diabetes management often requires multiple daily insulin injections, associated with pain and inadequate glycemia control. Herein, we have developed an ultrasound-triggered insulin delivery system capable of pulsatile insulin release that can provide both long-term sustained and fast on-demand responses. In this system, insulin-loaded poly(lactic-co-glycolic acid) (PLGA) nanocapsules are encapsulated within chitosan microgels. The encapsulated insulin in nanocapsules can passively diffuse from the nanoparticle but remain restricted within the microgel. Upon ultrasound treatment, the stored insulin in microgels can be rapidly released to regulate blood glucose levels. In a chemically-induced type 1 diabetic mouse model, we demonstrated that this system, when activated by 30 s ultrasound administration, could effectively achieve glycemic control for up to one week in a noninvasive, localized, and pulsatile manner.

Graphical Abstract

Publisher

Tsinghua University Press

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