A titanium dioxide nanorod array as a high-affinity nano-bio interface of a microfluidic device for efficient capture of circulating tumor cells
TiO2 nanorod array, circulating tumor cell, microfluidic device, nano-bio interface, 3D hierarchical structure
ABSTRACT Nanomaterials show promising opportunities to address clinical problems (such as insufficient capture of circulating tumor cells; CTCs) via the high surface area-to-volume ratio and high affinity for biological cells. However, how to apply these nanomaterials as a nano-bio interface in a microfluidic device for efficient CTC capture with high specificity remains a challenge. In the present work, we first found that a titanium dioxide (TiO2) nanorod array that can be conveniently prepared on multiple kinds of substrates has high affinity for tumor cells. Then, the TiO2 nanorod array was vertically grown on the surface of a microchannel with hexagonally patterned Si micropillars via a hydrothermal reaction, forming a new kind of a micro-nano 3D hierarchically structured microfluidic device. The vertically grown TiO2 nanorod array was used as a sensitive nano-bio interface of this 3D hierarchically structured microfluidic device, which showed high efficiency of CTC capture (76.7% ± 7.1%) in an artificial whole-blood sample.
Tsinghua University Press
Jichuan Qiu,Kun Zhao,Linlin Li,Xin Yu,Weibo Guo,Shu Wang,Xiaodi Zhang,Caofeng Pan,Zhong Lin Wang,Hong Liu, A titanium dioxide nanorod array as a high-affinity nano-bio interface of a microfluidic device for efficient capture of circulating tumor cells. NanoRes.2017, 10(3): 776–784