Real-time electrical detection of epidermal skin MoS2 biosensor for point-of-care diagnostics
epidermal skin biomarker, MoS2, biosensor, real-time, point-of-care diagnostics
ABSTRACT Various approaches have been proposed for point-of-care diagnostics, and in particular, optical detection is preferred because it is relatively simple and fast. At the same time, field-effect transistor (FET)-based biosensors have attracted great attention because they can provide highly sensitive and label-free detection. In this work, we present highly sensitive, epidermal skin-type point-of-care devices with system-level integration of flexible MoS2 FET biosensors, read-out circuits, and light-emitting diode (LEDs) that enable real-time detection of prostate cancer antigens (PSA). Regardless of the physical forms or mechanical stress conditions, our proposed high-performance MoS2 biosensors can detect a PSA concentration of 1 pg·mL–1 without specific surface treatment for anti-PSA immobilization on the MoS2 surface on which we characterize and confirm physisorption of anti-PSA using Kelvin probe force microscopy (KPFM) and tapping-mode atomic force microscopy (tm-AFM). Furthermore, current modulation induced by the binding process was stably maintained for longer than 2–3 min. The results indicate that flexible MoS2-based FET biosensors have great potential for point-of-care diagnostics for prostate cancer as well as other biomarkers.
Tsinghua University Press
Geonwook Yoo,Heekyeong Park,Minjung Kim,Won Geun Song,Seokhwan Jeong,Min Hyung Kim,Hyungbeen Lee,Sang Woo Lee,Young Ki Hong,Min Goo Lee,Sungho Lee,Sunkook Kim, Real-time electrical detection of epidermal skin MoS2 biosensor for point-of-care diagnostics. NanoRes.2017, 10(3): 767–775