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Nano Research

Article Title

General synthesis of high-performing magneto-conjugated polymer core–shell nanoparticles for multifunctional theranostics

Authors

Hao Yan, State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 00084, China Key Laboratory of Advanced Materials of Ministry of Education of China, Tsinghua University, Beijing 100084, China Engineering Laboratory for Functionalized Carbon Materials, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China
Lingyun Zhao, State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 00084, China Key Laboratory of Advanced Materials of Ministry of Education of China, Tsinghua University, Beijing 100084, China
Wenting Shang, Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China
Zhongqun Liu, State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 00084, China Key Laboratory of Advanced Materials of Ministry of Education of China, Tsinghua University, Beijing 100084, China
Wensheng Xie, State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 00084, China Key Laboratory of Advanced Materials of Ministry of Education of China, Tsinghua University, Beijing 100084, China
Cai Qiang, State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 00084, China Key Laboratory of Advanced Materials of Ministry of Education of China, Tsinghua University, Beijing 100084, China
Zhiyuan Xiong, Key Laboratory of Advanced Materials of Ministry of Education of China, Tsinghua University, Beijing 100084, China
Ranran Zhang, State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 00084, China Key Laboratory of Advanced Materials of Ministry of Education of China, Tsinghua University, Beijing 100084, China
Baohua Li, Engineering Laboratory for Functionalized Carbon Materials, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China
Xiaodan Sun, State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 00084, China Key Laboratory of Advanced Materials of Ministry of Education of China, Tsinghua University, Beijing 100084, China
Feiyu Kang, State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 00084, China Engineering Laboratory for Functionalized Carbon Materials, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China

Keywords

iron oxide, polypyrrole, photothermal, magnetic, hyperthermal, poly(3, 4- ethylenedioxythiophene): poly(4-styrenesulfonate) (PEDOT:PSS)

Abstract

ABSTRACT Recently, increasing attention has been paid to magneto-conjugated polymer core–shell nanoparticles (NPs) as theranostic platforms. However, the utilization of surfactants and extra oxidizing agents with potential toxicity in synthesis, the lack of general methods for the controlled synthesis of various kinds of magnetic NP (MNP)@conjugated polymer NPs, and the difficulty of obtaining balanced magneto-optical properties have greatly limited the applications of magneto-conjugated polymers in theranostics. We developed an in situ surface polymerization method free of extra surfactants and oxidizing agents to synthesize MNP@polypyrrole (PPy) NPs with balanced, prominent magneto-optical properties. MNP@PPy NPs with an adjustable size, different shapes, and a controlled shell thickness were obtained using this method. The method was extended to synthesize other MNP-conjugated polymer core–shell NPs, such as MNP@polyaniline and MNP@poly(3,4-ethylenedioxythiophene):poly(4- styrenesulfonate) (PEDOT:PSS). We discuss the formation mechanism of the proposed method according to our experimental results. Finally, using the optical and magnetic properties of the obtained MNP@PEDOT:PSS NPs, in vivo multimodal imaging-guided hyperthermia was induced in mice, achieving an excellent tumor-ablation therapeutic effect. Our work is beneficial for extending the application of MNP-conjugated polymer core–shell NPs in the biomedical field.

Graphical Abstract

Publisher

Tsinghua University Press

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