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Nano Research

Article Title

Generic synthesis and versatile applications of molecularly organic–inorganic hybrid mesoporous organosilica nanoparticles with asymmetric Janus topologies and structures

Authors

Guiju Tao, Key Laboratory of Materials for High Power Laser, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800, China Sinopec Shanghai Research Institute of Petrochemical Technology, Shanghai 201208, China
Zhengyuan Bai, Key Laboratory of Materials for High Power Laser, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800, China
Yu Chen, State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China
Heliang Yao, Analysis and Testing Center for Inorganic Materials, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China
Meiying Wu, State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China
Ping Huang, State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China
Luodan Yu, State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China
Jiamin Zhang, Shanghai (Red Cross) Blood Center, Shanghai Institute of Blood Transfusion, Shanghai 200051, China
Chen Dai, Department of Ultrasound, the East Hospital Affiliated to Tongji University, Shanghai 200120, China
Long Zhang, Key Laboratory of Materials for High Power Laser, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800, China

Keywords

mesoporous organosilica, Janus, synthetic mechanism, drug carrier, blood compatibility

Abstract

ABSTRACT Precise control over the morphology, nanostructure, composition, and particle size of molecularly organic–inorganic hybrid mesoporous organosilica nanoparticles (MONs) still remains a major challenge, which severely restricts their broad applications. In this work, an efficient bridged organic group-determined growth strategy has been proposed for the facile synthesis of highly dispersed and uniform MONs with multifarious Janus morphologies, nanostructures, organic–inorganic hybrid compositions, and particle sizes, which can be easily controlled simply by varying the bridged organic groups and the concentration of bis-silylated organosilica precursors used in the synthesis. In addition, the formation mechanism of Janus MONs determined by the bridged organic group has been discussed. Based on the specific structures, compositions, and asymmetric morphologies, all the synthesized Janus MONs with hollow structures (JHMONs) demonstrate excellent performances in nanomedicine as desirable drug carriers with high drug-loading efficiencies/capacities, pH-responsive drug releasing, and enhanced therapeutic efficiencies, as attractive contrastenhanced contrast agents for ultrasound imaging, and as excellent bilirubin adsorbents with noticeably high adsorption capacities and high blood compatibilities. The developed versatile synthetic strategy and the obtained JHMONs are extremely important in the development and applications of MONs, particularly in the areas of nanoscience and nanotechnology.

Graphical Abstract

Publisher

Tsinghua University Press

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